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Pulmonary hypertension in systemic lupus erythematosus: echocardiography-based definitions predict 6-year survival.
Hübbe-Tena, Claudia; Gallegos-Nava, Selma; Márquez-Velasco, Ricardo; Castillo-Martínez, Diana; Vargas-Barrón, Jesus; Sandoval, Julio; Amezcua-Guerra, Luis M.
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  • Hübbe-Tena C; Department of Rheumatology, Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Department of Dermatology, Hospital General de Zona 1-A Dr Rodolfo Antonio de Mucha Macías, Instituto Mexicano del Seguro Social, Division of Research, Department of Echocardiography and Cardio Re
  • Gallegos-Nava S; Department of Rheumatology, Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Department of Dermatology, Hospital General de Zona 1-A Dr Rodolfo Antonio de Mucha Macías, Instituto Mexicano del Seguro Social, Division of Research, Department of Echocardiography and Cardio Re
  • Márquez-Velasco R; Department of Rheumatology, Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Department of Dermatology, Hospital General de Zona 1-A Dr Rodolfo Antonio de Mucha Macías, Instituto Mexicano del Seguro Social, Division of Research, Department of Echocardiography and Cardio Re
  • Castillo-Martínez D; Department of Rheumatology, Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Department of Dermatology, Hospital General de Zona 1-A Dr Rodolfo Antonio de Mucha Macías, Instituto Mexicano del Seguro Social, Division of Research, Department of Echocardiography and Cardio Re
  • Vargas-Barrón J; Department of Rheumatology, Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Department of Dermatology, Hospital General de Zona 1-A Dr Rodolfo Antonio de Mucha Macías, Instituto Mexicano del Seguro Social, Division of Research, Department of Echocardiography and Cardio Re
  • Sandoval J; Department of Rheumatology, Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Department of Dermatology, Hospital General de Zona 1-A Dr Rodolfo Antonio de Mucha Macías, Instituto Mexicano del Seguro Social, Division of Research, Department of Echocardiography and Cardio Re
  • Amezcua-Guerra LM; Department of Rheumatology, Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Department of Dermatology, Hospital General de Zona 1-A Dr Rodolfo Antonio de Mucha Macías, Instituto Mexicano del Seguro Social, Division of Research, Department of Echocardiography and Cardio Re
Rheumatology (Oxford) ; 53(7): 1256-63, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24599923
OBJECTIVE: The aim of this study was to investigate whether a core of echocardiography-based definitions of pulmonary hypertension (PH), as proposed by the European Society of Cardiology, European Respiratory Society and International Society of Heart and Lung Transplantation (ESC/ERS/ISHLT), may predict long-term survival in patients with SLE. METHODS: A post hoc analysis from a cohort of SLE patients followed over 6 years was performed. Clinical associations, serum biomarkers, autoantibody profile, length of survival and all-cause mortality were assessed. RESULTS: Out of 115 patients from the original cohort, 55 satisfied our inclusion criteria and were grouped according to echocardiography as unlikely (n = 26), possible (n = 16) or likely (n = 13) to have PH. Likely PH was associated with a history of pulmonary thromboembolism, higher cumulated organ damage and active arthritis. The 6-year survival rate was 88% in the unlikely PH group, 87% in the possible PH group and 68% in the likely PH group (P < 0.05). Serum levels of endothelin-1, monocyte chemotactic protein-1, IL-17, and IFN-γ as well as a number of autoantibodies were no different between groups. CONCLUSION: The ESC/ERS/ISHLT echocardiography-based definitions of PH are useful to predict 6-year mortality in SLE patients. A history of pulmonary thromboembolism and lung vasculitis/haemorrhage, cumulated organ damage and long-lasting disease are associated with PH in SLE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ecocardiografía / Hipertensión Pulmonar / Lupus Eritematoso Sistémico Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ecocardiografía / Hipertensión Pulmonar / Lupus Eritematoso Sistémico Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido