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Meta-analysis of the rs4779584 polymorphism and colorectal cancer risk.
Yang, Hua; Gao, Ya; Feng, Tian; Jin, Tian-Bo; Kang, Long-Li; Chen, Chao.
Afiliación
  • Yang H; School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
  • Gao Y; School of Medicine, Xi'an Jiaotong University, Xi'an, China.
  • Feng T; National Engineering Research Center for Miniaturized Detection Systems, Xi'an, Shaanxi, China.
  • Jin TB; School of Life Sciences, Northwest University, Xi'an, Shaanxi, China ; National Engineering Research Center for Miniaturized Detection Systems, Xi'an, Shaanxi, China ; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Tibet Univ
  • Kang LL; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Tibet University for Nationalities, Xianyang, Shaanxi, China.
  • Chen C; School of Life Sciences, Northwest University, Xi'an, Shaanxi, China ; National Engineering Research Center for Miniaturized Detection Systems, Xi'an, Shaanxi, China.
PLoS One ; 9(2): e89736, 2014.
Article en En | MEDLINE | ID: mdl-24586997
PURPOSE: Several researchers have suggested that the rs4779584 (15q13.3) polymorphism is associated with an increased risk of developing colorectal cancer (CRC). However, past results remain inconclusive. We addressed this controversy by performing a meta-analysis of the relationship between rs4779584 of GREM1-SCG5 and colorectal cancer. METHODS: We selected 12 case-control studies involving 11,769 cases of CRC and 14,328 healthy controls. The association between the rs4779584 polymorphism and CRC was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used different genetic model analyses, sensitivity analyses, and assessments of bias in our meta-analysis. RESULTS: GREM1-SCG5 rs4779584 polymorphisms were associated with CRC in all of the genetic models that were examined in this meta-analysis of 12 case-control studies. CONCLUSION: GREM1-SCG5 rs4779584 polymorphisms may increase the risk of developing colorectal cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 15 / Neoplasias Colorrectales / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 15 / Neoplasias Colorrectales / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos