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Clinicopathological prognostic factors of oral tongue squamous cell carcinoma: a retrospective study of 202 cases.
Rodrigues, P C; Miguel, M C C; Bagordakis, E; Fonseca, F P; de Aquino, S N; Santos-Silva, A R; Lopes, M A; Graner, E; Salo, T; Kowalski, L P; Coletta, R D.
Afiliación
  • Rodrigues PC; Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
  • Miguel MC; Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil; Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Bagordakis E; Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
  • Fonseca FP; Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
  • de Aquino SN; Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
  • Santos-Silva AR; Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
  • Lopes MA; Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
  • Graner E; Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
  • Salo T; Department of Diagnostics and Oral Medicine, Institute of Dentistry and Oulu University Hospital and Medical Research Center, University of Oulu, Oulu, Finland; Institute of Dentistry, University of Helsinki, Helsinki, Finland.
  • Kowalski LP; Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.
  • Coletta RD; Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil. Electronic address: coletta@fop.unicamp.br.
Int J Oral Maxillofac Surg ; 43(7): 795-801, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24583139
Although several histopathological parameters and grading systems have been described as predictive of the treatment response and outcome of oral squamous cell carcinoma (OSCC), none is universally accepted. A new scoring system, the histological risk model, was recently described to be a powerful predictive tool for recurrence and overall survival in OSCC. The aim of this study was to verify the predictive role of the histological risk model in a cohort of 202 patients at all stages of oral/mobile tongue squamous cell carcinoma (OTSCC). Demographic and clinical data were collected from the medical records and the tumours were evaluated using the histological risk model. Statistical analyses were performed using the χ(2) test, the Kaplan-Meier method, and the Cox regression model. The histological risk model showed no statistical correlation with demographic or clinical parameters and did not Predict the outcome of the OTSCC patients. However, multivariate regression analysis revealed a significant correlation of the clinical disease stage with the disease outcome. Despite major efforts to identify new predictive parameters and histological systems, clinical features are still the most reliable prognostic factors for patients with OTSCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Neoplasias de la Lengua / Carcinoma de Células Escamosas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Oral Maxillofac Surg Asunto de la revista: ODONTOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Neoplasias de la Lengua / Carcinoma de Células Escamosas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Oral Maxillofac Surg Asunto de la revista: ODONTOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Dinamarca