Multiple mitochondrial alterations in a case of myopathy.
Ultrastruct Pathol
; 38(3): 204-10, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-24579828
Mitochondrial alterations are the most common feature of human myopathies. A biopsy of quadriceps muscle from a 50-year-old woman exhibiting myopathic symptoms was examined by transmission electron microscopy. Biopsied fibers from quadriceps muscle displayed numerous subsarcolemmal mitochondria that contained crystalloids. Numbering 1-6 per organelle, these consisted of rows of punctuate densities measuring â¼0.34 nm; the parallel rows of these dots had a periodicity of â¼0.8 nm. The crystalloids were ensconced within cristae or in the outer compartment. Some mitochondria without crystalloids had circumferential cristae, leaving a membrane-free center that was filled with a farinaceous material. Other scattered fibrocyte defects included disruption of the contractile apparatus or its sporadic replacement by a finely punctuate material in some myofibers. Intramitochondrial crystalloids, although morphologically striking, do not impair organelle physiology to a significant degree, so the muscle weakness of the patient must originate elsewhere.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fibras Musculares Esqueléticas
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Músculo Cuádriceps
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Mitocondrias Musculares
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Enfermedades Musculares
Límite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Ultrastruct Pathol
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Reino Unido