Design of prodrugs to enhance colonic absorption by increasing lipophilicity and blocking ionization.

Nofsinger, Rebecca; Clas, Sophie-Dorothee; Sanchez, Rosa I; Walji, Abbas; Manser, Kimberly; Nissley, Becky; Balsells, Jaume; Nair, Amrithraj; Dang, Qun; Bennett, David Jonathan; Hafey, Michael; Wang, Junying; Higgins, John; Templeton, Allen; Coleman, Paul; Grobler, Jay; Smith, Ronald; Wu, Yunhui

Nofsinger, Rebecca; Clas, Sophie-Dorothee; Sanchez, Rosa I; Walji, Abbas; Manser, Kimberly; Nissley, Becky; Balsells, Jaume; Nair, Amrithraj; Dang, Qun; Bennett, David Jonathan; Hafey, Michael; Wang, Junying; Higgins, John; Templeton, Allen; Coleman, Paul; Grobler, Jay; Smith, Ronald; Wu, Yunhui.

Afiliación

Nofsinger R; Biopharmaceutics, Pharmaceutical Science, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Rebecca_nofsinger@merck.com.
Clas SD; Discovery Pharmaceutical Sciences, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. sdclas@pharmasolv.com.
Sanchez RI; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Rosa_Sanchez@merck.com.
Walji A; Medicinal Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Abbas_Walji@merck.com.
Manser K; Biopharmaceutics, Pharmaceutical Science, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Kimberly_Manser@merck.com.
Nissley B; Biopharmaceutics, Pharmaceutical Science, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Becky_Nissley@merck.com.
Balsells J; Process Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Jaume_Balsells@merck.com.
Nair A; Toxicology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Amrithraj_Nair@merck.com.
Dang Q; Medicinal Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Qun_Dang@merck.com.
Bennett DJ; Medicinal Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Jonathan.Bennett@merck.com.
Hafey M; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Michael_Hafey@merck.com.
Wang J; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Junying_Wang@merck.com.
Higgins J; Discovery Pharmaceutical Sciences, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. John_Higgins3@merck.com.
Templeton A; Discovery Pharmaceutical Sciences, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Allen_Templeton@merck.com.
Coleman P; Medicinal Chemistry, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Paul_Coleman@merck.com.
Grobler J; Biology, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Jay_Grobler@merck.com.
Smith R; Formulation Sciences, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Ronald_Smithl@merck.com.
Wu Y; Biopharmaceutics, Pharmaceutical Science, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA. Yunhui_Wu@merck.com.

Pharmaceuticals (Basel) ; 7(2): 207-19, 2014 Feb 24.

Article en En | MEDLINE | ID: mdl-24566521

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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