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Arterial stiffness and influences of the metabolic syndrome: a cross-countries study.
Scuteri, Angelo; Cunha, Pedro G; Agabiti Rosei, E; Badariere, Jolita; Bekaert, Sofie; Cockcroft, John R; Cotter, Jorge; Cucca, Francesco; De Buyzere, Marc L; De Meyer, Tim; Ferrucci, Luigi; Franco, Osca; Gale, Nichola; Gillebert, Thierry C; Hofman, A; Langlois, Michel; Laucevicius, Aleksandras; Laurent, Stephane; Mattace Raso, Francesco U S; Morrell, Cristopher H; Muiesan, Maria Lorenza; Munnery, Margaret M; Navickas, Rokas; Oliveira, Pedro; Orru', Marco; Pilia, Maria Grazia; Rietzschel, Ernst R; Ryliskyte, Ligita; Salvetti, Massimo; Schlessinger, David; Sousa, Nuno; Stefanadis, Christodoulos; Strait, James; Van Daele, Caroline; Villa, Isabel; Vlachopoulos, Charalambos; Witteman, Jacqueline; Xaplanteris, Panagiotis; Nilsson, Peter; Lakatta, Edward G.
Afiliación
  • Scuteri A; San Raffaele Pisana (HSR) IRCCS, Rome, Italy. Electronic address: angeloelefante@interfree.it.
  • Cunha PG; Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Internal Medicine Department, Guimarães, Centro Hospitalar do Alto Ave/Minho University, Guimaraes Braga, Portugal; Life and Health Science Research Institute (ICVS), School of Health Science, University of Minho
  • Agabiti Rosei E; Dipartimento di Scienze Cliniche e Sperimentali, Università di Brescia, 2° Medicina Generale Spedali Civili, Brescia, Italy.
  • Badariere J; Clinic of Cardiovascular Diseases, Medical Faculty, Vilnius University, Vilnius, Lithuania; Centre of Cardiology and Angiology, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania.
  • Bekaert S; Bimetra, Clinical Research Center Ghent, Ghent University Hospital, Ghent, Belgium.
  • Cockcroft JR; Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff, UK.
  • Cotter J; Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Internal Medicine Department, Guimarães, Centro Hospitalar do Alto Ave/Minho University, Guimaraes Braga, Portugal; Life and Health Science Research Institute (ICVS), School of Health Science, University of Minho
  • Cucca F; Institute of Genetics and Biomedic Research (IRGB), Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
  • De Buyzere ML; Department of Cardiovascular Diseases, Ghent University Hospital and Ghent University, Ghent, Belgium.
  • De Meyer T; Dept. of Mathematical Modelling, Statistics and Bioinformatics, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.
  • Ferrucci L; Scientific Director, IRP NIA, NIH, Baltimore, USA.
  • Franco O; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Gale N; Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff, UK.
  • Gillebert TC; Department of Cardiovascular Diseases, Ghent University Hospital and Ghent University, Ghent, Belgium.
  • Hofman A; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Langlois M; Clinical Chemistry, AZ Sint-Jan Bruges Hospital, Asklepios Core Lab, and Department of Cardiovascular Diseases, Ghent University, Ghent, Belgium.
  • Laucevicius A; Clinic of Cardiovascular Diseases, Medical Faculty, Vilnius University, Vilnius, Lithuania; Centre of Cardiology and Angiology, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania.
  • Laurent S; Department of Pharmacology, Pompidou Hospital, INSERM U970 and University Paris Descartes, Paris, France.
  • Mattace Raso FUS; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Morrell CH; Laboratory Cardiovascular Sciences, National Institute on Aging (NIA), NIH, Baltimore, USA; Loyola College, Baltimore, USA.
  • Muiesan ML; Dipartimento di Scienze Cliniche e Sperimentali, Università di Brescia, 2° Medicina Generale Spedali Civili, Brescia, Italy.
  • Munnery MM; Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff, UK.
  • Navickas R; Clinic of Cardiovascular Diseases, Medical Faculty, Vilnius University, Vilnius, Lithuania; Centre of Cardiology and Angiology, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania.
  • Oliveira P; Departamento de Estudo de Populações, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
  • Orru' M; Institute of Genetics and Biomedic Research (IRGB), Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
  • Pilia MG; Institute of Genetics and Biomedic Research (IRGB), Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
  • Rietzschel ER; Department of Cardiovascular Diseases, Ghent University Hospital and Ghent University, Ghent, Belgium.
  • Ryliskyte L; Clinic of Cardiovascular Diseases, Medical Faculty, Vilnius University, Vilnius, Lithuania; Centre of Cardiology and Angiology, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania.
  • Salvetti M; Dipartimento di Scienze Cliniche e Sperimentali, Università di Brescia, 2° Medicina Generale Spedali Civili, Brescia, Italy.
  • Schlessinger D; Laboratory of Genetics, National Institute on Aging (NIA), NIH, Baltimore, USA.
  • Sousa N; Life and Health Science Research Institute (ICVS), School of Health Science, University of Minho, Guimaraes Braga, Portugal; ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal.
  • Stefanadis C; 1st Department of Cardiology, Athens Medical School, Athens, Greece.
  • Strait J; Laboratory Cardiovascular Sciences, National Institute on Aging (NIA), NIH, Baltimore, USA.
  • Van Daele C; Department of Cardiovascular Diseases, Ghent University Hospital and Ghent University, Ghent, Belgium.
  • Villa I; Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk, Internal Medicine Department, Guimarães, Centro Hospitalar do Alto Ave/Minho University, Guimaraes Braga, Portugal.
  • Vlachopoulos C; 1st Department of Cardiology, Athens Medical School, Athens, Greece.
  • Witteman J; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Xaplanteris P; 1st Department of Cardiology, Athens Medical School, Athens, Greece.
  • Nilsson P; Department of Clinical Sciences, Lund University, University Hospital, Malmö, Sweden.
  • Lakatta EG; Laboratory Cardiovascular Sciences, National Institute on Aging (NIA), NIH, Baltimore, USA.
Atherosclerosis ; 233(2): 654-660, 2014 Apr.
Article en En | MEDLINE | ID: mdl-24561493
Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigate whether specific clusters of MetS are consistently associated with stiffer arteries in different populations. We studied 20,570 subjects from 9 cohorts representing 8 different European countries and the US participating in the MARE Consortium. MetS was defined in accordance with NCEP ATPIII criteria as the simultaneous alteration in ≥3 of the 5 components: abdominal obesity (W), high triglycerides (T), low HDL cholesterol (H), elevated blood pressure (B), and elevated fasting glucose (G). PWV measured in each cohort was "normalized" to account for different acquisition methods. MetS had an overall prevalence of 24.2% (4985 subjects). MetS accelerated the age-associated increase in PWV levels at any age, and similarly in men and women. MetS clusters TBW, GBW, and GTBW are consistently associated with significantly stiffer arteries to an extent similar or greater than observed in subjects with alteration in all the five MetS components--even after controlling for age, sex, smoking, cholesterol levels, and diabetes mellitus--in all the MARE cohorts. In conclusion, different component clusters of MetS showed varying associations with arterial stiffness (PWV).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Metabólico / Rigidez Vascular Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Europa Idioma: En Revista: Atherosclerosis Año: 2014 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Metabólico / Rigidez Vascular Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Europa Idioma: En Revista: Atherosclerosis Año: 2014 Tipo del documento: Article Pais de publicación: Irlanda