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Thirty and ninety days mortality predictive value of admission and in-hospital procalcitonin and mid-regional pro-adrenomedullin testing in patients with dyspnea. Results from the VERyfing DYspnea trial.
Travaglino, Francesco; Russo, Veronica; De Berardinis, Benedetta; Numeroso, Filippo; Catania, Pamela; Cervellin, Gianfranco; Nigra, Stefano Geniere; Geraci, Francesco; Bressan, Maria Antonietta; Guerrini, Stefania; Cavazza, Mario; Folli, Christian; Monzani, Valter; Battista, Stefania; Mengozzi, Giulio; Noto, Paola; Carpinteri, Giuseppe; Semplicini, Andrea; Stella, Federica; Ingrassia, Stella; Moscatelli, Paolo; Giuntini, Patrizia; Salerno, Gerardo; Cardelli, Patrizia; Di Somma, Salvatore.
Afiliación
  • Travaglino F; Emergency Department, Sant'Andrea Hospital, School of Medicine and Psychology "Sapienza" Univesity, Rome, Italy. Electronic address: francesco.travaglino@gmail.com.
  • Russo V; Emergency Department, Sant'Andrea Hospital, School of Medicine and Psychology "Sapienza" Univesity, Rome, Italy. Electronic address: veryo85@hotmail.it.
  • De Berardinis B; Emergency Department, Sant'Andrea Hospital, School of Medicine and Psychology "Sapienza" Univesity, Rome, Italy. Electronic address: benedetta.db@gmail.com.
  • Numeroso F; Emergency Medicine Department, Parma Teaching Hospital, Parma, Italy. Electronic address: FNumeroso@ao.pr.it.
  • Catania P; Emergency Medicine Department, Parma Teaching Hospital, Parma, Italy. Electronic address: pamelacatania@live.com.
  • Cervellin G; Emergency Medicine Department, Parma Teaching Hospital, Parma, Italy. Electronic address: GCervellin@ao.pr.it.
  • Nigra SG; Emergency Medicine Department, San Matteo Teaching Hospital, Pavia, Italy. Electronic address: stefano.genierenigra@email.it.
  • Geraci F; Emergency Medicine Department, San Matteo Teaching Hospital, Pavia, Italy. Electronic address: francescogeraci@gmail.com.
  • Bressan MA; Emergency Medicine Department, San Matteo Teaching Hospital, Pavia, Italy. Electronic address: m.bressan@smatteo.pv.it.
  • Guerrini S; Emergency Medicine Department, S. Orsola-Malpighi Teaching Hospital, Bologna, Italy. Electronic address: stefania.guerrini@aosp.bo.it.
  • Cavazza M; Emergency Medicine Department, S. Orsola-Malpighi Teaching Hospital, Bologna, Italy. Electronic address: mario.cavazza@aosp.bo.it.
  • Folli C; Emergency Medicine Department, Maggiore Teaching Hospital, Milan, Italy. Electronic address: christian.folli@policlinico.mi.it.
  • Monzani V; Emergency Medicine Department, Maggiore Teaching Hospital, Milan, Italy. Electronic address: vmonzani@policlinico.mi.it.
  • Battista S; Emergency Medicine Department, Città della Scienza e della Salute Hospital, Turin, Italy. Electronic address: stefania.battista@libero.it.
  • Mengozzi G; Emergency Medicine Department, Città della Scienza e della Salute Hospital, Turin, Italy. Electronic address: gmengozzi@cittadellasalute.to.it.
  • Noto P; Emergency Medicine Department, Vittorio Emanuele Teaching Hospital, Catania, Italy. Electronic address: p.noto@hotmail.it.
  • Carpinteri G; Emergency Medicine Department, Vittorio Emanuele Teaching Hospital, Catania, Italy. Electronic address: gcarpinteri@gmail.com.
  • Semplicini A; Internal Medicine Department, SS Giovanni e Paolo Hospital in Venice, University of Padua, Italy. Electronic address: andrea.semplicini@unipd.it.
  • Stella F; Internal Medicine Department, SS Giovanni e Paolo Hospital in Venice, University of Padua, Italy. Electronic address: fede.stella@gmail.com.
  • Ingrassia S; Emergency Medicine Department, San Martino Teaching Hospital, Cenoa University, Italy. Electronic address: stella99@alice.it.
  • Moscatelli P; Emergency Medicine Department, San Martino Teaching Hospital, Cenoa University, Italy. Electronic address: moscatellievandro@gmail.com.
  • Giuntini P; Emergency Medicine Department, San Martino Teaching Hospital, Cenoa University, Italy. Electronic address: patriziagiuntini53@gmail.com.
  • Salerno G; Clinical and Molecular Medicine Department Sant'Andrea Hospital, School of Medicine and Psychology "Sapienza" Univesity, Rome, Italy. Electronic address: sagerardo@libero.it.
  • Cardelli P; Clinical and Molecular Medicine Department Sant'Andrea Hospital, School of Medicine and Psychology "Sapienza" Univesity, Rome, Italy. Electronic address: patrizia.cardelli@uniroma1.it.
  • Di Somma S; Emergency Department, Sant'Andrea Hospital, School of Medicine and Psychology "Sapienza" Univesity, Rome, Italy. Electronic address: salvatore.disomma@uniroma1.it.
Am J Emerg Med ; 32(4): 334-41, 2014 Apr.
Article en En | MEDLINE | ID: mdl-24559907
INTRODUCTION: Mid-regional pro-atrial natriuretic peptide (MR-proANP), procalcitonin (PCT), and mid-regional pro-adrenomedullin (MR-proADM) demonstrated usefulness for management of emergency department patients with dyspnea. METHODS: To evaluate in patients with dyspnea, the prognostic value for 30 and 90 days mortality and readmission of PCT, MR-proADM, and MR-proANP, a multicenter prospective study was performed evaluating biomarkers at admission, 24 and 72 hours after admission. Based on final diagnosis, patients were divided into acute heart failure (AHF), primary lung diseases, or both (AHF + NO AHF). RESULTS: Five hundred one patients were enrolled. Procalcitonin and MR-proADM values at admission and at 72 hours were significantly (P < .001) predictive for 30-day mortality: baseline PCT with an area under the curve (AUC) of 0.70 and PCT at 72 hours with an AUC of 0.61; baseline MR-proADM with an AUC of 0.62 and MR-proADM at 72 hours with an AUC of 0.68. As for 90-day mortality, both PCT and MR-proADM baseline and 72 hours values showed a significant (P < .0001) predictive ability: baseline PCT with an AUC of 0.73 and 72 hours PCT with an AUC of 0.64; baseline MR-proADM with an AUC of 0.66 and 72 hours MR-proADM with an AUC of 0.71. In AHF, group biomarkers predicted rehospitalization and mortality at 90 days, whereas in AHF + NO AHF group, they predict mortality at 30 and 90 days. CONCLUSIONS: In patients admitted for dyspnea, assessment of PCT plus MR-proADM improves risk stratification and management. Combined use of biomarkers is able to predict in the total cohort both rehospitalization and death at 30 and 90 days.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Precursores de Proteínas / Calcitonina / Disnea / Adrenomedulina / Insuficiencia Cardíaca / Enfermedades Pulmonares Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Am J Emerg Med Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Precursores de Proteínas / Calcitonina / Disnea / Adrenomedulina / Insuficiencia Cardíaca / Enfermedades Pulmonares Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Am J Emerg Med Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos