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New insights into the role of Plg-RKT in macrophage recruitment.
Miles, Lindsey A; Lighvani, Shahrzad; Baik, Nagyung; Parmer, Caitlin M; Khaldoyanidi, Sophia; Mueller, Barbara M; Parmer, Robert J.
Afiliación
  • Miles LA; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA. Electronic address: lmiles@scripps.edu.
  • Lighvani S; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
  • Baik N; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
  • Parmer CM; Department of Cell, Molecular and Developmental Biology, Yale University, New Haven, Connecticut, USA.
  • Khaldoyanidi S; Torrey Pines Institute for Molecular Studies, San Diego, California, USA.
  • Mueller BM; Torrey Pines Institute for Molecular Studies, San Diego, California, USA.
  • Parmer RJ; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, Veterans Administration San Diego Healthcare System, San Diego, California, USA.
Int Rev Cell Mol Biol ; 309: 259-302, 2014.
Article en En | MEDLINE | ID: mdl-24529725
Plasminogen (PLG) is the zymogen of plasmin, the major enzyme that degrades fibrin clots. In addition to its binding and activation on fibrin clots, PLG also specifically interacts with cell surfaces where it is more efficiently activated by PLG activators, compared with the reaction in solution. This results in association of the broad-spectrum proteolytic activity of plasmin with cell surfaces that functions to promote cell migration. Here, we review emerging data establishing a role for PLG, plasminogen receptors and the newly discovered plasminogen receptor, Plg-RKT, in macrophage recruitment in the inflammatory response, and we address mechanisms by which the interplay between PLG and its receptors regulates inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasminógeno / Receptores de Superficie Celular / Macrófagos Límite: Animals / Humans Idioma: En Revista: Int Rev Cell Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasminógeno / Receptores de Superficie Celular / Macrófagos Límite: Animals / Humans Idioma: En Revista: Int Rev Cell Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos