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Redox-activated MRI contrast agents based on lanthanide and transition metal ions.
Tsitovich, Pavel B; Burns, Patrick J; McKay, Adam M; Morrow, Janet R.
Afiliación
  • Tsitovich PB; Department of Chemistry, University at Buffalo, State University of New York, Amherst, NY 14260, United States.
  • Burns PJ; Department of Chemistry, University at Buffalo, State University of New York, Amherst, NY 14260, United States.
  • McKay AM; Department of Chemistry, University at Buffalo, State University of New York, Amherst, NY 14260, United States.
  • Morrow JR; Department of Chemistry, University at Buffalo, State University of New York, Amherst, NY 14260, United States. Electronic address: jmorrow@buffalo.edu.
J Inorg Biochem ; 133: 143-54, 2014 Apr.
Article en En | MEDLINE | ID: mdl-24529651
The reduction/oxidation (redox) potential of tissue is tightly regulated in order to maintain normal physiological processes, but is disrupted in disease states. Thus, the development of new tools to map tissue redox potential may be clinically important for the diagnosis of diseases that lead to redox imbalances. One promising area of chemical research is the development of redox-activated probes for mapping tissue through magnetic resonance imaging (MRI). In this review, we summarize several strategies for the design of redox-responsive MRI contrast agents. Our emphasis is on both lanthanide(III) and transition metal(II/III) ion complexes that provide contrast either as T1 relaxivity MRI contrast agents or as paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents. These agents are redox-triggered by a variety of chemical reactions or switches including redox-activated thiol groups, and heterocyclic groups that interact with the metal ion or influence properties of other ancillary ligands. Metal ion centered redox is an approach which is ripe for development by coordination chemists. Redox-triggered metal ion approaches have great potential for creating large differences in magnetic properties that lead to changes in contrast. An attractive feature of these agents is the ease of fine-tuning the metal ion redox potential over a biologically relevant range.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Imagen por Resonancia Magnética / Medios de Contraste / Elementos de la Serie de los Lantanoides Límite: Humans Idioma: En Revista: J Inorg Biochem Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Imagen por Resonancia Magnética / Medios de Contraste / Elementos de la Serie de los Lantanoides Límite: Humans Idioma: En Revista: J Inorg Biochem Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos