Your browser doesn't support javascript.
loading
Pathophysiological and physicochemical basis of ammonium urate stone formation in dolphins.
Smith, Cynthia R; Poindexter, John R; Meegan, Jennifer M; Bobulescu, Ion Alexandru; Jensen, Eric D; Venn-Watson, Stephanie; Sakhaee, Khashayar.
Afiliación
  • Smith CR; National Marine Mammal Foundation, San Diego, California.
  • Poindexter JR; Department of Internal Medicine and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Meegan JM; National Marine Mammal Foundation, San Diego, California.
  • Bobulescu IA; Department of Internal Medicine and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Jensen ED; United States Navy Marine Mammal Program, Space and Naval Warfare Systems Center Pacific, San Diego, California.
  • Venn-Watson S; National Marine Mammal Foundation, San Diego, California.
  • Sakhaee K; Department of Internal Medicine and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: khashayar.sakhaee@utsouthwestern.edu.
J Urol ; 192(1): 260-6, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24518786
PURPOSE: Nephrolithiasis is increasingly reported in bottle-nosed dolphins. All cases to date have been ammonium urate nephrolithiasis. MATERIALS AND METHODS: A case-control study was performed in dolphins with and without evidence of nephrolithiasis to identify biomarkers and risk factors associated with stone formation in a managed population. Dolphins were sampled in fasting and postprandial states to study the effect of dietary factors on serum and urinary biochemistry. Urine was continuously collected for 6 hours via catheter and divided into 3, 2-hour collections with a bolus fish meal given after completing the first collection. Blood was sampled at the beginning of the fasting period and the end of the postprandial period. RESULTS: There were no significant differences in serum and urine chemistry or acid-base profiles between dolphins with vs without stones at baseline or postprandially. This suggests that cases and controls represent a continuum of stone risk. On analysis combining cases and controls in a single cohort we noted significant postprandial increases in urinary uric acid, sulfate and net acid excretion accompanied by increased urinary ammonium excretion and a commensurate increase in urine pH. The supersaturation index of ammonium urate increased more than twofold postprandially. CONCLUSIONS: These findings suggest that dolphins are susceptible to ammonium urate nephrolithiasis at least in part because a high dietary load of acid and purines results in a transient but marked increase in the urinary supersaturation of the sparingly soluble ammonium urate salt.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Úrico / Delfín Mular / Nefrolitiasis Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Urol Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Úrico / Delfín Mular / Nefrolitiasis Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Urol Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos