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Chymase activities and survival in endotoxin-induced human chymase transgenic mice.
Rafiq, Kazi; Fan, Yu-Yan; Sherajee, Shamshad J; Takahashi, Yoshimasa; Matsuura, Junji; Hase, Naoki; Mori, Hirohito; Nakano, Daisuke; Kobara, Hideki; Hitomi, Hirofumi; Masaki, Tsutomu; Urata, Hidenori; Nishiyama, Akira.
Afiliación
  • Rafiq K; 1. Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
  • Fan YY; 1. Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
  • Sherajee SJ; 1. Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
  • Takahashi Y; 2. Teijin Institute for Bio-Medical Research, Teijin Pharma Ltd., Tokyo, Japan.
  • Matsuura J; 2. Teijin Institute for Bio-Medical Research, Teijin Pharma Ltd., Tokyo, Japan.
  • Hase N; 2. Teijin Institute for Bio-Medical Research, Teijin Pharma Ltd., Tokyo, Japan.
  • Mori H; 3. Department of Gastroenterology and Neurology, Kagawa University Medical School, Kagawa, Japan.
  • Nakano D; 1. Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
  • Kobara H; 3. Department of Gastroenterology and Neurology, Kagawa University Medical School, Kagawa, Japan.
  • Hitomi H; 1. Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
  • Masaki T; 3. Department of Gastroenterology and Neurology, Kagawa University Medical School, Kagawa, Japan.
  • Urata H; 4. Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
  • Nishiyama A; 1. Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan.
Int J Med Sci ; 11(3): 222-5, 2014.
Article en En | MEDLINE | ID: mdl-24516344
We examined the effects of overexpressed human chymase on survival and activity in lipopolysaccharide (LPS)-treated mice. Human chymase transgenic (Tg) and wild-type C57BL/6 (WT) mice were treated with LPS (0.03, 0.1 and 0.3 mg/day; intraperitoneal) for 2 weeks. Treatment with 0.03 mg LPS did not affect survival in either WT or Tg mice. WT mice were not affected by 0.1 mg/day of LPS, whereas 25% of Tg mice died. Survival of mice treated with 0.3 mg/day of LPS was 87.5% and 0% in WT and Tg, respectively. LPS-induced increases in chymase activity in the heart and skin were significantly greater in Tg than WT mice. These data suggest a possible contribution of human chymase activation to LPS-induced mortality.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Regulación Enzimológica de la Expresión Génica / Quimasas / Miocardio Límite: Animals / Humans Idioma: En Revista: Int J Med Sci Asunto de la revista: MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Regulación Enzimológica de la Expresión Génica / Quimasas / Miocardio Límite: Animals / Humans Idioma: En Revista: Int J Med Sci Asunto de la revista: MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia