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Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential.
Choo, Siew Woh; Wee, Wei Yee; Ngeow, Yun Fong; Mitchell, Wayne; Tan, Joon Liang; Wong, Guat Jah; Zhao, Yongbing; Xiao, Jingfa.
Afiliación
  • Choo SW; 1] Genome Informatics Research Laboratory, High Impact Research (HIR) Building, University of Malaya, 50603 Kuala Lumpur, Malaysia [2] Department of Oral Biology & Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • Wee WY; 1] Genome Informatics Research Laboratory, High Impact Research (HIR) Building, University of Malaya, 50603 Kuala Lumpur, Malaysia [2] Department of Oral Biology & Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • Ngeow YF; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • Mitchell W; 1] Division of Information Sciences, School of Computer Engineering, Nanyang Technological University, Singapore [2] Synthetic Biology Group, Lanzatech, Auckland, New Zealand.
  • Tan JL; 1] Genome Informatics Research Laboratory, High Impact Research (HIR) Building, University of Malaya, 50603 Kuala Lumpur, Malaysia [2] Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • Wong GJ; 1] Genome Informatics Research Laboratory, High Impact Research (HIR) Building, University of Malaya, 50603 Kuala Lumpur, Malaysia [2] Department of Oral Biology & Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • Zhao Y; 1] CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
  • Xiao J; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
Sci Rep ; 4: 4061, 2014 Feb 11.
Article en En | MEDLINE | ID: mdl-24515248
Mycobacterium abscessus (Ma) is an emerging human pathogen that causes both soft tissue infections and systemic disease. We present the first comparative whole-genome study of Ma strains isolated from patients of wide geographical origin. We found a high proportion of accessory strain-specific genes indicating an open, non-conservative pan-genome structure, and clear evidence of rapid phage-mediated evolution. Although we found fewer virulence factors in Ma compared to M. tuberculosis, our data indicated that Ma evolves rapidly and therefore should be monitored closely for the acquisition of more pathogenic traits. This comparative study provides a better understanding of Ma and forms the basis for future functional work on this important pathogen.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Bacteriano / Evolución Biológica / Mycobacterium / Infecciones por Mycobacterium Límite: Humans Idioma: En Revista: Sci Rep Año: 2014 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Bacteriano / Evolución Biológica / Mycobacterium / Infecciones por Mycobacterium Límite: Humans Idioma: En Revista: Sci Rep Año: 2014 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido