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Oxidant-antioxidant status in Egyptian children with sickle cell anemia: a single center based study.
El-Ghamrawy, Mona Kamal; Hanna, Wagdi Maurice; Abdel-Salam, Amina; El-Sonbaty, Marwa M; Youness, Eman R; Adel, Ahmed.
Afiliación
  • El-Ghamrawy MK; Department of Pediatrics, New Children's Hospital, Cairo University, Cairo, Egypt. Electronic address: melghamrawi@yahoo.com.
  • Hanna WM; Department of Child Health, National Research Center, Cairo, Egypt.
  • Abdel-Salam A; Department of Pediatrics, New Children's Hospital, Cairo University, Cairo, Egypt.
  • El-Sonbaty MM; Department of Child Health, National Research Center, Cairo, Egypt.
  • Youness ER; Department of Medical Biochemistry, National Research Center, Cairo, Egypt.
  • Adel A; Department of Child Health, National Research Center, Cairo, Egypt.
J Pediatr (Rio J) ; 90(3): 286-92, 2014.
Article en En | MEDLINE | ID: mdl-24508012
OBJECTIVE: the present study was conducted to investigate the oxidant-antioxidant status in Egyptian children with sickle cell anemia. METHODS: the serum levels of total antioxidant capacity (TAO), paraoxonase (PON), vitamin E, nitrite, and malondialdehyde (MDA) were measured in 40 steady state children with homozygous sickle cell anemia (24 males and 16 females) and 20 apparently healthy age- and gender-matched controls. RESULTS: mean serum TAO, PON, vitamin E, and nitrite levels were significantly lower in the group with sickle cell anemia, whereas mean serum MDA was significantly higher in these children compared to controls. No significant differences in mean levels of TAO, PON, nitrite, vitamin E, and MDA were found in sickle cell anemia patients receiving hydroxyurea when compared with those not receiving hydroxyurea. A significant negative correlation between serum nitrite and the occurrence of vaso-occlusive crises (VOC) was observed (r=-0.3, p=0.04). PON level was found to be positively correlated with patients' weight and BMI (r=-0.4, p=0.01; r=-0.7, p<0.001, respectively), but not with frequency of VOC. The area under the curve of serum nitrite in predicting occurrence of VOC was 0.782, versus 0.701 for PON, and 0.650 for TAO (p=0.006). Serum MDA was not correlated with nitrite, PON, TAO, or vitamin E levels. No significant correlations were detected between serum nitrite and hemoglobin or antioxidant enzymes. CONCLUSION: children with sickle cell anemia have chronic oxidative stress that may result in increased VOC, and decreased serum nitrite may be associated with increases in VOC frequency. A novel finding in this study is the decrease in PON level in these patients, which is an interesting subject for further research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidantes / Anemia de Células Falciformes / Antioxidantes Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: J Pediatr (Rio J) Año: 2014 Tipo del documento: Article Pais de publicación: Brasil
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidantes / Anemia de Células Falciformes / Antioxidantes Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: J Pediatr (Rio J) Año: 2014 Tipo del documento: Article Pais de publicación: Brasil