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Effect of verapamil and lidocaine on TRPM and NaV1.9 gene expressions in renal ischemia-reperfusion.
Dusmez, D; Cengiz, B; Yumrutas, O; Demir, T; Oztuzcu, S; Demiryurek, S; Tutar, E; Bayraktar, R; Bulut, A; Simsek, H; Dagli, S Nur; Kilic, T; Bagci, C.
Afiliación
  • Dusmez D; Department of Medical Physiology, Faculty of Medicine, University of Gaziantep, Turkey.
  • Cengiz B; Department of Medical Physiology, Faculty of Medicine, University of Gaziantep, Turkey. Electronic address: beyhancengiz@gmail.com.
  • Yumrutas O; Department of Medical Biology, Faculty of Medicine, University of Adiyaman, Turkey.
  • Demir T; Department of Medical Physiology, Faculty of Medicine, University of Gaziantep, Turkey.
  • Oztuzcu S; Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Turkey.
  • Demiryurek S; Department of Medical Physiology, Faculty of Medicine, University of Gaziantep, Turkey.
  • Tutar E; Department of Pathology, Faculty of Medicine, University of Gaziantep, Turkey.
  • Bayraktar R; Department of Medical Physiology, Faculty of Medicine, University of Gaziantep, Turkey; Department of Medical Biology, Faculty of Medicine, University of Gaziantep, Turkey.
  • Bulut A; Department of Medical Physiology, Faculty of Medicine, University of Adiyaman, Turkey.
  • Simsek H; Department of Medical Physiology, Faculty of Medicine, University of Dumlupinar, Kutahya, Turkey.
  • Dagli SN; Department of Medical Physiology, Faculty of Medicine, University of Harran, Sanliufa, Turkey.
  • Kilic T; Department of Medical Physiology, Faculty of Medicine, University of Gaziantep, Turkey.
  • Bagci C; Department of Medical Physiology, Faculty of Medicine, University of Gaziantep, Turkey.
Transplant Proc ; 46(1): 33-9, 2014.
Article en En | MEDLINE | ID: mdl-24507022
BACKGROUND: To determine effects on calcium and sodium channels of Ca(2+) and Na(+) channel blockers in the present study, expression levels of TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, and NaV1.9 genes were evaluated in kidney tissues after induced ischemia-reperfusion. MATERIAL AND METHODS: Forty albino Wistar male rats were equally divided into 4 groups as follows: group I: control group (n = 10), group II: ischemia group (60 minutes of ischemia + 48 hours of reperfusion; n = 10), group III: ischemia (60 minutes of ischemia + 48 hours of reperfusion) + calcium channel blocker (n = 8), group IV: ischemia (60 minutes of ischemia + 48 hours of reperfusion) + sodium channel blocker (n = 8). RESULTS: When compared to ischemia group expression levels of TRPM2, TRPM4, TRPM6, and NaV1.9 in Ca(2+) and Na(+) channel blocker groups were increased, whereas that of TRPM7 was decreased. However, expression levels of TRPM1, TRPM3, TRPM5, and TRPM8 were not determined in kidney tissue. Histologically, the Ca(2+) channel blocker verapamil and the Na(+) channel blocker lidocaine inhibited the cell death in kidney tissue compared to control. CONCLUSION: Our study suggested that verapamil and lidocaine significantly reduce the degree of ischemia-reperfusion injury due to effects to TRPM and Nav1.9 genes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bloqueadores de los Canales de Calcio / Verapamilo / Daño por Reperfusión / Regulación de la Expresión Génica / Canales Catiónicos TRPM / Canal de Sodio Activado por Voltaje NAV1.9 / Bloqueadores del Canal de Sodio Activado por Voltaje / Riñón / Enfermedades Renales / Lidocaína Límite: Animals Idioma: En Revista: Transplant Proc Año: 2014 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bloqueadores de los Canales de Calcio / Verapamilo / Daño por Reperfusión / Regulación de la Expresión Génica / Canales Catiónicos TRPM / Canal de Sodio Activado por Voltaje NAV1.9 / Bloqueadores del Canal de Sodio Activado por Voltaje / Riñón / Enfermedades Renales / Lidocaína Límite: Animals Idioma: En Revista: Transplant Proc Año: 2014 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos