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Polyurethane-based scaffolds for myocardial tissue engineering.
Chiono, Valeria; Mozetic, Pamela; Boffito, Monica; Sartori, Susanna; Gioffredi, Emilia; Silvestri, Antonella; Rainer, Alberto; Giannitelli, Sara Maria; Trombetta, Marcella; Nurzynska, Daria; Di Meglio, Franca; Castaldo, Clotilde; Miraglia, Rita; Montagnani, Stefania; Ciardelli, Gianluca.
Afiliación
  • Chiono V; Department of Mechanical and Aerospace Engineering , Politecnico di Torino , Corso Duca degli Abruzzi 24, Turin , Italy.
  • Mozetic P; Tissue Engineering Laboratory , Università 'Campus Bio-Medico di Roma' , Via Alvaro del Portillo 21, Rome , Italy.
  • Boffito M; Department of Mechanical and Aerospace Engineering , Politecnico di Torino , Corso Duca degli Abruzzi 24, Turin , Italy.
  • Sartori S; Department of Mechanical and Aerospace Engineering , Politecnico di Torino , Corso Duca degli Abruzzi 24, Turin , Italy.
  • Gioffredi E; Department of Mechanical and Aerospace Engineering , Politecnico di Torino , Corso Duca degli Abruzzi 24, Turin , Italy.
  • Silvestri A; Department of Mechanical and Aerospace Engineering , Politecnico di Torino , Corso Duca degli Abruzzi 24, Turin , Italy.
  • Rainer A; Tissue Engineering Laboratory , Università 'Campus Bio-Medico di Roma' , Via Alvaro del Portillo 21, Rome , Italy.
  • Giannitelli SM; Tissue Engineering Laboratory , Università 'Campus Bio-Medico di Roma' , Via Alvaro del Portillo 21, Rome , Italy.
  • Trombetta M; Tissue Engineering Laboratory , Università 'Campus Bio-Medico di Roma' , Via Alvaro del Portillo 21, Rome , Italy.
  • Nurzynska D; Department of Public Health , University of Naples 'Federico II' , Via Pansini 5, Naples , Italy.
  • Di Meglio F; Department of Public Health , University of Naples 'Federico II' , Via Pansini 5, Naples , Italy.
  • Castaldo C; Department of Public Health , University of Naples 'Federico II' , Via Pansini 5, Naples , Italy.
  • Miraglia R; Department of Public Health , University of Naples 'Federico II' , Via Pansini 5, Naples , Italy.
  • Montagnani S; Department of Public Health , University of Naples 'Federico II' , Via Pansini 5, Naples , Italy.
  • Ciardelli G; Department of Mechanical and Aerospace Engineering , Politecnico di Torino , Corso Duca degli Abruzzi 24, Turin , Italy.
Interface Focus ; 4(1): 20130045, 2014 Feb 06.
Article en En | MEDLINE | ID: mdl-24501673
Bi-layered scaffolds with a 0°/90° lay-down pattern were prepared by melt-extrusion additive manufacturing (AM) using a poly(ester urethane) (PU) synthesized from poly(ε-caprolactone) diol, 1,4-butandiisocyanate and l-lysine ethyl ester dihydrochloride chain extender. Rheological analysis and differential scanning calorimetry of the starting material showed that compression moulded PU films were in the molten state at a higher temperature than 155°C. The AM processing temperature was set at 155°C after verifying the absence of PU thermal degradation phenomena by isothermal thermogravimetry analysis and rheological characterization performed at 165°C. Scaffolds highly reproduced computer-aided design geometry and showed an elastomeric-like behaviour which is promising for applications in myocardial regeneration. PU scaffolds supported the adhesion and spreading of human cardiac progenitor cells (CPCs), whereas they did not stimulate CPC proliferation after 1-14 days culture time. In the future, scaffold surface functionalization with bioactive peptides/proteins will be performed to specifically guide CPC behaviour.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Interface Focus Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Interface Focus Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido