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Transforming growth factor-ß1 in plaque morphea.
Danczak-Pazdrowska, Aleksandra; Kowalczyk, Michal J; Szramka-Pawlak, Beata; Gornowicz-Porowska, Justyna; Szewczyk, Aleksandra; Silny, Wojciech; Molinska-Glura, Marta; Olewicz-Gawlik, Anna; Zaba, Ryszard; Pazdrowski, Jakub; Hrycaj, Pawel.
Afiliación
  • Danczak-Pazdrowska A; Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Zygmunt Adamski MD, PhD.
  • Kowalczyk MJ; Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Zygmunt Adamski MD, PhD.
  • Szramka-Pawlak B; Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Zygmunt Adamski MD, PhD.
  • Gornowicz-Porowska J; Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Zygmunt Adamski MD, PhD.
  • Szewczyk A; Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Zygmunt Adamski MD, PhD.
  • Silny W; Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Zygmunt Adamski MD, PhD.
  • Molinska-Glura M; Chair and Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Jerzy A. Moczko.
  • Olewicz-Gawlik A; Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Pawel Hrycaj MD, PhD.
  • Zaba R; Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Zygmunt Adamski MD, PhD.
  • Pazdrowski J; Head and Neck Department, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Prof. Wojciech Golusinski MD, PhD.
  • Hrycaj P; Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Pawel Hrycaj MD, PhD.
Postepy Dermatol Alergol ; 30(6): 337-42, 2013 Dec.
Article en En | MEDLINE | ID: mdl-24493995
INTRODUCTION: Morphea (localized scleroderma) is a rare cutaneous disease characterized by skin fibrosis of unknown pathogenesis. Transforming growth factor-ß (TGF-ß) is a potent profibrotic factor. The role of TGF-ß in morphea remains unclear. AIM: The goal of this study was to estimate the expression level of TGF-ß1 in skin and peripheral blood mononuclear cells as well as the plasma levels of TGF-ß1 in plaque morphea (MEP). MATERIAL AND METHODS: The study involved 20 MEP patients. Three control groups were involved: 1 - plasma: 36 healthy volunteers; 2 - PBMC: 47 healthy volunteers; 3 - skin biopsies: 13 samples collected during mastectomy (breast cancer was not skin involved). The analysis of TGF-ß1 plasma levels was performed with the use an adequate ELISA kit, while real-time polymerase chain reaction was employed for the expression of TGF-ß1 in peripheral blood mononuclear cells (PBMC) and skin. RESULTS: In our study we have not detected differences in TGF-ß 1 expression in PBMC, skin, nor in plasma levels of TGF-ß1 between MEP patients and healthy controls, regardless of disease activity and its duration. CONCLUSIONS: The results of our study contradict the claim of the substantial role of TGF-ß1 in the most common morphea subtype - MEP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Postepy Dermatol Alergol Año: 2013 Tipo del documento: Article Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Postepy Dermatol Alergol Año: 2013 Tipo del documento: Article Pais de publicación: Polonia