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HGF accelerates wound healing by promoting the dedifferentiation of epidermal cells through ß1-integrin/ILK pathway.
Li, Jin-Feng; Duan, Hai-Feng; Wu, Chu-Tse; Zhang, Da-Jin; Deng, Youping; Yin, Hong-Lei; Han, Bing; Gong, Hui-Cui; Wang, Hong-Wei; Wang, Yun-Liang.
Afiliación
  • Li JF; The Neurology Department of the 148th Hospital, 20 Zhanbei Road, Zibo 255300, China.
  • Duan HF; Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
  • Wu CT; Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
  • Zhang DJ; Medical Research Center of Naval General Hospital, 6 Fucheng Road, Beijing 10037, China.
  • Deng Y; Wuhan University of Science and Technology, Wuhan, Hubei 430081, China.
  • Yin HL; The Neurology Department of the 148th Hospital, 20 Zhanbei Road, Zibo 255300, China.
  • Han B; The Neurology Department of the 148th Hospital, 20 Zhanbei Road, Zibo 255300, China.
  • Gong HC; The Neurology Department of the 148th Hospital, 20 Zhanbei Road, Zibo 255300, China.
  • Wang HW; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.
  • Wang YL; The Neurology Department of the 148th Hospital, 20 Zhanbei Road, Zibo 255300, China.
Biomed Res Int ; 2013: 470418, 2013.
Article en En | MEDLINE | ID: mdl-24490163
Skin wound healing is a critical and complex biological process after trauma. This process is activated by signaling pathways of both epithelial and nonepithelial cells, which release a myriad of different cytokines and growth factors. Hepatocyte growth factor (HGF) is a cytokine known to play multiple roles during the various stages of wound healing. This study evaluated the benefits of HGF on reepithelialization during wound healing and investigated its mechanisms of action. Gross and histological results showed that HGF significantly accelerated reepithelialization in diabetic (DB) rats. HGF increased the expressions of the cell adhesion molecules ß1-integrin and the cytoskeleton remodeling protein integrin-linked kinase (ILK) in epidermal cells in vivo and in vitro. Silencing of ILK gene expression by RNA interference reduced expression of ß1-integrin, ILK, and c-met in epidermal cells, concomitantly decreasing the proliferation and migration ability of epidermal cells. ß1-Integrin can be an important maker of poorly differentiated epidermal cells. Therefore, these data demonstrate that epidermal cells become poorly differentiated state and regained some characteristics of epidermal stem cells under the role of HGF after wound. Taken together, the results provide evidence that HGF can accelerate reepithelialization in skin wound healing by dedifferentiation of epidermal cells in a manner related to the ß1-integrin/ILK pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Proteínas Serina-Treonina Quinasas / Factor de Crecimiento de Hepatocito / Integrina beta1 Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2013 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Proteínas Serina-Treonina Quinasas / Factor de Crecimiento de Hepatocito / Integrina beta1 Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2013 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos