Click chemistry approach: regioselective one-pot synthesis of some new 8-trifluoromethylquinoline based 1,2,3-triazoles as potent antimicrobial agents.

Garudachari, B; Isloor, Arun M; Satyanarayana, M N; Fun, Hoong-Kun; Hegde, Gurumurthy

Garudachari, B; Isloor, Arun M; Satyanarayana, M N; Fun, Hoong-Kun; Hegde, Gurumurthy.

Afiliación

Garudachari B; Medicinal Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore 575 025, India.
Isloor AM; Medicinal Chemistry Laboratory, Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore 575 025, India. Electronic address: isloor@yahoo.com.
Satyanarayana MN; Department of Physics, National Institute of Technology Karnataka, Surathkal, Mangalore 575 025, India.
Fun HK; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Hegde G; Faculty of Industrial Science and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300 Gambang, Kuantan, Pahang Darul Makmur, Malaysia.

Eur J Med Chem ; 74: 324-32, 2014 Mar 03.

Article en En | MEDLINE | ID: mdl-24486415

RESUMEN

Three series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a-c, 6a-d and 7a-c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against tested microbial strains. The results are summarized in Tables 5 and 6.

Asunto(s)

Antiinfecciosos/síntesis química; Quinolinas/química; Triazoles/síntesis química; Antiinfecciosos/química; Química Clic; Espectroscopía de Resonancia Magnética; Modelos Moleculares; Triazoles/química

Palabras clave

1,2,3-Triazole; 8-Trifluoromethylquinoline; Antimicrobial activity; Click chemistry; Suzuki coupling

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinolinas / Triazoles / Antiinfecciosos Idioma: En Revista: Eur J Med Chem Año: 2014 Tipo del documento: Article País de afiliación: India Pais de publicación: Francia

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google