Effects of medazepam on voltage-gated ion currents of cultured chick sensory neurons.
Eur J Pharmacol
; 143(3): 373-81, 1987 Nov 17.
Article
en En
| MEDLINE
| ID: mdl-2446893
The effects of the benzodiazepine, medazepam, were investigated in current and voltage-clamped cultured chick dorsal root ganglion neurons. Under current clamp, micromolar concentrations initially elevated the action potential threshold and blocked both the sodium and calcium components of the spike. In voltage clamp, low (I(Ca.T)) and high (I(CA.N/L)) threshold calcium, sodium (I(Na)) and the delayed rectifier potassium (I(K)) currents were isolated by the use of appropriate solutions and voltage command protocols. Medazepam depressed both subtypes of I(Ca) equally well with calculated half-maximal depression at 77 microM. At a fixed concentration of 200 microM, medazepam depressed I(Na) (70 +/- 9%) and I(K) (73 +/- 6%) to a degree comparable to I(Ca) (75 +/- 3%). The results show that benzodiazepines can modulate the activity of several voltage-gated ion currents in chick dorsal root ganglion neurons.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ansiolíticos
/
Canales Iónicos
/
Medazepam
/
Neuronas Aferentes
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Países Bajos