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Genes and evolution of two-domain toxins from lynx spider venom.
Sachkova, Maria Y; Slavokhotova, Anna A; Grishin, Eugene V; Vassilevski, Alexander A.
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  • Sachkova MY; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya, 117997 Moscow, Russian Federation. Electronic address: sachkovamasha@mail.ru.
  • Slavokhotova AA; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya, 117997 Moscow, Russian Federation; N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkina, 119991 Moscow, Russian Federation.
  • Grishin EV; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya, 117997 Moscow, Russian Federation.
  • Vassilevski AA; M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya, 117997 Moscow, Russian Federation. Electronic address: avas@ibch.ru.
FEBS Lett ; 588(5): 740-5, 2014 Mar 03.
Article en En | MEDLINE | ID: mdl-24462682
Spiderines are comparatively long polypeptide toxins (∼110 residues) from lynx spiders (genus Oxyopes). They are built of an N-terminal linear cationic domain (∼40 residues) and a C-terminal knottin domain (∼60 residues). The linear domain empowers spiderines with strong cytolytic activity. In the present work we report 16 novel spiderine sequences from Oxyopes takobius and Oxyopes lineatus classified into two subfamilies. Strikingly, negative selection acts on both linear and knottin domains. Genes encoding Oxyopes two-domain toxins were sequenced and found to be intronless. We further discuss a possible scenario of lynx spider modular toxin evolution.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arañas / Proteínas de Insectos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: FEBS Lett Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arañas / Proteínas de Insectos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: FEBS Lett Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido