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Pentraxin 3 (PTX3) plasma levels and carotid intima media thickness progression in the general population.
Baragetti, A; Knoflach, M; Cuccovillo, I; Grigore, L; Casula, M; Garlaschelli, K; Mantovani, A; Wick, G; Kiechl, S; Willeit, J; Bottazzi, B; Catapano, A L; Norata, G D.
Afiliación
  • Baragetti A; Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Milan, Italy; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Italy.
  • Knoflach M; Department of Neurology, Medical University Innsbruck, Austria.
  • Cuccovillo I; Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
  • Grigore L; Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Milan, Italy.
  • Casula M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Italy.
  • Garlaschelli K; Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Milan, Italy.
  • Mantovani A; Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy; Department of Translational Medicine, University of Milan, Milan, Italy.
  • Wick G; Laboratory of Autoimmunity, Biocenter, Innsbruck, Austria.
  • Kiechl S; Department of Neurology, Medical University Innsbruck, Austria.
  • Willeit J; Department of Neurology, Medical University Innsbruck, Austria.
  • Bottazzi B; Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
  • Catapano AL; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Italy; IRCCS Multimedica, Milan, Italy. Electronic address: alberico.catapano@unimi.it.
  • Norata GD; Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Milan, Italy; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Italy; The Blizard Institute, Centre for Diabetes, Barts and The London School of Medicine & Dentistry, Queen Mar
Nutr Metab Cardiovasc Dis ; 24(5): 518-23, 2014 May.
Article en En | MEDLINE | ID: mdl-24462365
BACKGROUND AND AIM: Pentraxin 3 (PTX3) is an essential component of the humoral arm of innate immunity and, like C-reactive protein, is independently associated with the risk of developing vascular events. Aim of this study was to investigate, in two large population-based surveys, the Bruneck Study and the PLIC Study, whether PTX3 plasma levels predict the progression of common carotid artery intima-media thickness (CCA-IMT), a surrogate marker of atherosclerosis, in the general population during 5 or 6 years of follow-up. RESULTS: In the Bruneck Study, PTX3 plasma levels did not predict a faster progression of CCA-IMT either in the carotid artery or in the femoral artery. This finding was confirmed in the PLIC Study where subjects within the highest tertile of PTX3 did not show an increased progression of CCA-IMT. PTX3 plasma levels were also not associated with the fastest maximum IMT progression. In summary, in more than 2400 subjects from the general population, PTX3 plasma level is neither an independent predictor of progression of subclinical atherosclerosis in different arterial territories, including carotid and femoral arteries nor of incident cardiovascular events. CONCLUSION: These findings support the relevance of investigating the predictive value of PTX3 plasma levels only in specific settings, like overt CVD, heart failure or acute myocardial infarction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Componente Amiloide P Sérico / Biomarcadores / Grosor Intima-Media Carotídeo Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Componente Amiloide P Sérico / Biomarcadores / Grosor Intima-Media Carotídeo Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos