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Predicting the molecular interactions of CRIP1a-cannabinoid 1 receptor with integrated molecular modeling approaches.
Ahmed, Mostafa H; Kellogg, Glen E; Selley, Dana E; Safo, Martin K; Zhang, Yan.
Afiliación
  • Ahmed MH; Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA; Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Kellogg GE; Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA; Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA 23298, USA; Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA
  • Selley DE; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Safo MK; Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA; Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Zhang Y; Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address: yzhang2@vcu.edu.
Bioorg Med Chem Lett ; 24(4): 1158-65, 2014 Feb 15.
Article en En | MEDLINE | ID: mdl-24461351
Cannabinoid receptors are a family of G-protein coupled receptors that are involved in a wide variety of physiological processes and diseases. One of the key regulators that are unique to cannabinoid receptors is the cannabinoid receptor interacting proteins (CRIPs). Among them CRIP1a was found to decrease the constitutive activity of the cannabinoid type-1 receptor (CB1R). The aim of this study is to gain an understanding of the interaction between CRIP1a and CB1R through using different computational techniques. The generated model demonstrated several key putative interactions between CRIP1a and CB1R, including the critical involvement of Lys130 in CRIP1a.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Portadoras / Receptor Cannabinoide CB1 / Proteínas con Dominio LIM Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Portadoras / Receptor Cannabinoide CB1 / Proteínas con Dominio LIM Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido