Microbial production of 1α-hydroxyvitamin D3 from vitamin D3.
Nat Prod Res
; 28(7): 444-8, 2014.
Article
en En
| MEDLINE
| ID: mdl-24456427
The microbial transformation of vitamin D3 (1) by the fungi Candida maltosa R42 and Botrytis allii NRRL 2502 was investigated. Incubation of compound 1 with C. maltosa R42 and B. allii NRRL 2502 produced the same three more polar metabolites in small yields. The main metabolite was identified as 1α-hydroxyvitamin D3 (2). This biotransformation has utility as a possible tool for the production of 1α-hydroxyvitamin D3 from the readily available vitamin D3 for patients with compromised kidney function.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Candida
/
Colecalciferol
/
Botrytis
/
Hidroxicolecalciferoles
Límite:
Humans
Idioma:
En
Revista:
Nat Prod Res
Año:
2014
Tipo del documento:
Article
País de afiliación:
Egipto
Pais de publicación:
Reino Unido