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The effect of brain-derived neurotrophic factor on periodontal furcation defects.
Jimbo, Ryo; Tovar, Nick; Janal, Malvin N; Mousa, Ramy; Marin, Charles; Yoo, Daniel; Teixeira, Hellen S; Anchieta, Rodolfo B; Bonfante, Estevam A; Konishi, Akihiro; Takeda, Katsuhiro; Kurihara, Hidemi; Coelho, Paulo G.
Afiliación
  • Jimbo R; Department of Prosthodontics, Faculty of Odontology, Malmo University, Malmö, Sweden.
  • Tovar N; Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, New York, United States of America.
  • Janal MN; Department of Epidemiology and Health Promotion, New York University, New York, United States of America.
  • Mousa R; Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, New York, United States of America.
  • Marin C; Department of Dentistry, UNIGRANRIO, Duque de Caxias, Rio de Janeiro, Brazil ; Department of Prosthodontics, Integrated Center for Research, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
  • Yoo D; Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, New York, United States of America.
  • Teixeira HS; Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, New York, United States of America.
  • Anchieta RB; Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, New York, United States of America.
  • Bonfante EA; Department of Prosthodontics, Integrated Center for Research, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
  • Konishi A; Department of Dentistry, UNIGRANRIO, Duque de Caxias, Rio de Janeiro, Brazil ; Department of Prosthodontics, Integrated Center for Research, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
  • Takeda K; Department of Periodontal Medicine, Division of Applied Life Sciences, Hiroshima University Institute of Biomedical & Health Sciences, Minami-ku, Hiroshima, Japan.
  • Kurihara H; Department of Periodontal Medicine, Division of Applied Life Sciences, Hiroshima University Institute of Biomedical & Health Sciences, Minami-ku, Hiroshima, Japan.
  • Coelho PG; Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, New York, United States of America.
PLoS One ; 9(1): e84845, 2014.
Article en En | MEDLINE | ID: mdl-24454754
This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 µg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF (50 µg/ml) in HMW-HA, Group C: HMW-HA acid only, Group D: empty defect, or Group E: BDNF (500 µg/ml) in saline. The healing status for all groups was observed at different time-points with micro computed tomography. The animals were euthanized after 11 weeks, and the tooth-bone specimens were subjected to histologic processing. The results showed that all groups seemed to successfully regenerate the alveolar buccal bone, however, only Group A regenerated the entire periodontal tissue, i.e., alveolar bone, cementum and periodontal ligament. It is suggested that the use of BDNF in combination with a scaffold such as the hyaluronic acid in periodontal furcation defects may be an effective treatment option.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Defectos de Furcación / Factor Neurotrófico Derivado del Encéfalo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Defectos de Furcación / Factor Neurotrófico Derivado del Encéfalo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos