Effect of urethan anesthesia on cigarette smoke-induced airway injury in guinea pigs.
J Appl Physiol (1985)
; 63(1): 84-91, 1987 Jul.
Article
en En
| MEDLINE
| ID: mdl-2442132
The effect of urethan anesthesia on cigarette smoke-induced airway responsiveness and permeability was studied in the guinea pig. Airway responsiveness was determined by measuring changes to airway resistance to graded doses of aerosolized histamine, and mucosal permeability was determined by measuring the appearance of fluorescein isothiocyanate-dextran (FITC-D) in the blood and examining its distribution in lung tissue after it had been delivered to the lung in an aerosol. The results confirm previous studies that smoke exposure increased airway responsiveness and mucosal permeability. They also show that urethan anesthesia administered before smoke exposure prevented the smoke-related changes in airway reactivity and mucosal permeability. In animals that remained conscious during the smoke exposure, there was increased deposition of the dextran in the regions of the bronchioloalveolar junctions with a more rapid uptake of FITC-D into the blood. We postulate that, when urethan anesthesia is administered before smoke exposure, the exudative phase of the inflammatory reaction produced by smoke exposure is suppressed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Uretano
/
Fumar
/
Fluoresceína-5-Isotiocianato
/
Anestesia General
/
Pulmón
Límite:
Animals
Idioma:
En
Revista:
J Appl Physiol (1985)
Asunto de la revista:
FISIOLOGIA
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Estados Unidos