Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.

Asai, Hirohide; Ikezu, Seiko; Woodbury, Maya E; Yonemoto, Grant M S; Cui, Libin; Ikezu, Tsuneya

Asai, Hirohide; Ikezu, Seiko; Woodbury, Maya E; Yonemoto, Grant M S; Cui, Libin; Ikezu, Tsuneya.

Afiliación

Asai H; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts.
Ikezu S; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts.
Woodbury ME; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts.
Yonemoto GM; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts.
Cui L; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts.
Ikezu T; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts; Alzheimer's Disease Center, Boston University School of Medicine, Boston, Massachusetts. Electr

Am J Pathol ; 184(3): 808-18, 2014 Mar.

Article en En | MEDLINE | ID: mdl-24418258

Asunto(s)

Demencia Frontotemporal/genética; Degeneración Nerviosa/genética; Proteínas Serina-Treonina Quinasas/genética; Proteínas tau/genética; Animales; Modelos Animales de Enfermedad; Demencia Frontotemporal/metabolismo; Demencia Frontotemporal/patología; Ratones; Ratones Transgénicos; Mutación; Degeneración Nerviosa/metabolismo; Degeneración Nerviosa/patología; Neuronas/metabolismo; Neuronas/patología; Fosforilación; Proteínas Serina-Treonina Quinasas/metabolismo; Médula Espinal/patología; Tauopatías/genética; Tauopatías/metabolismo; Tauopatías/patología; Proteínas tau/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas tau / Proteínas Serina-Treonina Quinasas / Demencia Frontotemporal / Degeneración Nerviosa Límite: Animals Idioma: En Revista: Am J Pathol Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos

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