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AKR1B10, a good prognostic indicator in gastric cancer.
Yao, H B; Xu, Y; Chen, L G; Guan, T P; Ma, Y Y; He, X J; Xia, Y J; Tao, H-Q; Shao, Q S.
Afiliación
  • Yao HB; Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, Zhejiang, China.
  • Xu Y; Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, Zhejiang, China.
  • Chen LG; Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, Zhejiang, China.
  • Guan TP; Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, Zhejiang, China.
  • Ma YY; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou 310014, Zhejiang, China.
  • He XJ; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou 310014, Zhejiang, China.
  • Xia YJ; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou 310014, Zhejiang, China.
  • Tao HQ; Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou 310014, Zhejiang, China.
  • Shao QS; Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, Zhejiang, China. Electronic address: yhb0129@126.com.
Eur J Surg Oncol ; 40(3): 318-24, 2014 Mar.
Article en En | MEDLINE | ID: mdl-24406159
BACKGROUND AND OBJECTIVES: The aim of the study was to investigate the correlation between AKR1B10 expression and clinicopathological features of gastric cancer (GC). METHODS: Real-time polymerase chain reaction (RT-PCR) was performed to determine AKR1B10 mRNA expression. AKR1B10 protein levels were measured by immunohistochemistry. RESULTS: RT-PCR analysis confirmed that AKR1B10 was significantly down-regulated in gastric cancer compared with paired, normal mucosa. Immunohistochemistry revealed that the percentage of AKR1B10-positive specimens was lower in gastric carcinoma compared with normal specimens. The frequency of AKR1B10-positive GC specimens was higher in patients with tumor size <5 cm, no lymph node metastasis, no distant metastasis and lower tumor stages The mean survival time for patients in the AKR1B10-positive group was significantly higher compared with the AKR1B1-negative group. The 5-year survival rate for the AKR1B10-positive group was also significantly higher than for the AKR1B1-negative group. Cox regression analysis revealed that AKR1B10 expression is an independent prognostic factor of GC. CONCLUSIONS: Expression of AKR1B10 in gastric cancer was significantly associated with tumor size, lymph node metastasis, distance metastasis and TNM stage, and AKR1B10 may be a good prognostic indicator in gastric cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Adenocarcinoma / Biomarcadores de Tumor / Aldehído Reductasa Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Eur J Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Adenocarcinoma / Biomarcadores de Tumor / Aldehído Reductasa Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Eur J Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido