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HDL-C, triglycerides and carotid IMT: a meta-analysis of 21,000 patients with automated edge detection IMT measurement.
Touboul, Pierre-Jean; Labreuche, Julien; Bruckert, Eric; Schargrodsky, Herman; Prati, Patrizio; Tosetto, Alberto; Hernandez-Hernandez, Rafael; Woo, Kam-Sang; Silva, Honorio; Vicaut, Eric; Amarenco, Pierre.
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  • Touboul PJ; From INSERM U 698, Paris, France; Paris Diderot - Sorbonne Paris City University, Paris, France; Department of Neurology and Stroke Centre, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address: pjtw@Noos.Pa.
  • Labreuche J; From INSERM U 698, Paris, France; Department of Neurology and Stroke Centre, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Bruckert E; Department of Endocrinology, Pitié-Salpêtrière University Hospital, Pierre and Marie Curie University, Paris, France.
  • Schargrodsky H; Department of Cardiology, Buenos Aires Italian Hospital, Buenos Aires, Argentina.
  • Prati P; Department of Neurology, "Gervasutta" Hospital ASS 4, Udine, Italy.
  • Tosetto A; Department of Hematology, S. Bortolo Hospital, Vicenza, Italy.
  • Hernandez-Hernandez R; Hypertension and Cardiovascular Risk Factors Clinic, Clinical Pharmacology Unit, School of Medicine, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Venezuela.
  • Woo KS; School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
  • Silva H; Department of Cardiology, Buenos Aires Italian Hospital, Buenos Aires, Argentina; InterAmerican Foundation for Clinical Research, New York, USA.
  • Vicaut E; Paris Diderot - Sorbonne Paris City University, Paris, France; Department of Biostatistics, Fernand Widal Hospital, Paris, France.
  • Amarenco P; From INSERM U 698, Paris, France; Paris Diderot - Sorbonne Paris City University, Paris, France; Department of Neurology and Stroke Centre, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address: pierre.amarenco@bch.aphp.fr.
Atherosclerosis ; 232(1): 65-71, 2014 Jan.
Article en En | MEDLINE | ID: mdl-24401218
OBJECTIVE: Common carotid artery (CCA) intima-media thickness (IMT), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), but not triglyceride levels, are markers of future cardiovascular events. The relationship between these three factors is, however, unclear. METHODS: We included six large observational studies that used the same harmonized, B-mode ultrasound protocol, the same software for IMT measurement by automatic edge detection on CCA in a plaque-free region, following the Mannheim consensus, and certification of all sonographers. Using the best view of the CCA, the sonographer had to confirm that the quality index was ≥ 0.5 on a measurement performed on 10-mm length. We used individual data meta-analysis to estimate the cross-sectional associations of lipids with CCA-IMT. RESULTS: Overall, 21,587 patients with complete information on lipids and CCA-IMT were available. Age- and sex-adjusted CCA-IMT differed by -7.8 µm (95% CI -9.1 to -6.5 µm, P < 0.001) per 1 SD higher HDL-C level. After further adjustment for other atherosclerosis risk factors, the relationship was attenuated, but remained significant (regression coefficient, -3.7 µm; P < 0.001). This was found regardless of LDL-C levels (P for heterogeneity = 0.70). After adjustment for age and sex, triglycerides were positively associated with CCA-IMT, overall and in each LDL-C subgroup, but not after further adjustments for other risk factors. CONCLUSIONS: Relationships between HDL-C and triglyceride levels and CCA-IMT were consistent with that previously observed with clinical events by the Emergency Risk Collaboration group, including at low LDL-C levels. This reinforces the need to verify whether raising HDL-C levels decreases both CCA-IMT and future clinical events.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triglicéridos / Arteria Carótida Común / Grosor Intima-Media Carotídeo / HDL-Colesterol Tipo de estudio: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Atherosclerosis Año: 2014 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triglicéridos / Arteria Carótida Común / Grosor Intima-Media Carotídeo / HDL-Colesterol Tipo de estudio: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Atherosclerosis Año: 2014 Tipo del documento: Article Pais de publicación: Irlanda