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BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease.
Bialecka, Monika; Kurzawski, Mateusz; Roszmann, Anna; Robowski, Piotr; Sitek, Emilia J; Honczarenko, Krystyna; Mak, Monika; Deptula-Jarosz, Monika; Golab-Janowska, Monika; Drozdzik, Marek; Slawek, Jaroslaw.
Afiliación
  • Bialecka M; Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstanców Wlkp 72, 70-111 Szczecin, Poland. Electronic address: monika-bialecka@post.pl.
  • Kurzawski M; Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstanców Wlkp 72, 70-111 Szczecin, Poland. Electronic address: mkurz@pum.edu.pl.
  • Roszmann A; Department of Neurological-Psychiatric Nursing, Medical University of Gdansk, Al. Jana Pawla II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawla II 50, 80-462 Gdansk, Poland. Electronic address: annaroszmann@gmail.com.
  • Robowski P; Department of Neurological-Psychiatric Nursing, Medical University of Gdansk, Al. Jana Pawla II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawla II 50, 80-462 Gdansk, Poland. Electronic address: piotr.amg@wp.pl.
  • Sitek EJ; Department of Neurological-Psychiatric Nursing, Medical University of Gdansk, Al. Jana Pawla II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawla II 50, 80-462 Gdansk, Poland. Electronic address: emsitek@gmail.com.
  • Honczarenko K; Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-251 Szczecin, Poland. Electronic address: khonczar@pum.edu.pl.
  • Mak M; Clinic of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland. Electronic address: monika.mak@gmail.com.
  • Deptula-Jarosz M; Department of Neurology, Marie Curie Regional Hospital, Arkonska 4, 71-455 Szczecin, Poland. Electronic address: jaroszki@interia.pl.
  • Golab-Janowska M; Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-251 Szczecin, Poland. Electronic address: monikagj@op.pl.
  • Drozdzik M; Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstanców Wlkp 72, 70-111 Szczecin, Poland. Electronic address: drozdzik@pum.edu.pl.
  • Slawek J; Department of Neurological-Psychiatric Nursing, Medical University of Gdansk, Al. Jana Pawla II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawla II 50, 80-462 Gdansk, Poland. Electronic address: jaroslawek@gumed.edu.pl.
Neurosci Lett ; 561: 86-90, 2014 Feb 21.
Article en En | MEDLINE | ID: mdl-24394906
Brain-derived neurotrophic factor (BDNF) is a neurotrophin widely expressed in the mammalian brain, regulating neuronal survival and known to influence dopaminergic neurons and cognitive processes. The present study investigated the BDNF Val66Met polymorphism associations with PD risk, and cognitive impairment in PD. A total of 486 study subjects (244 PD and 242 age and sex matched controls) were included in the study. UPDRS score, Hoehn-Yahr staging and the Schwab-England scale were used to assess motor abilities and activity during daily life. The patients were classified into groups with dementia (PDD, n=69) and without it (nPDD, n=166) on the basis of neuropsychological assessment. The most common functional polymorphism in BDNF Val66Met (rs6265, G196A) gene was determined using TaqMan real-time PCR assay. Frequencies of evaluated BDNF alleles and genotypes were similar in PD and the controls. The mean age of disease onset among BDNF Met/Met carriers was later (65.00±6.13) in comparison to Val/Val (57.45±10.68) and Val/Met (56.33±10.91) subjects (p=0.077). The studied BDNF polymorphism was not associated with cognitive status in PD patients. However, patients with Met/Met alleles demonstrated better delayed recall of information than patients with Val/Val alleles. The results of multivariate logistic regression analysis revealed age (p=0.0003) and the disease stage (p=0.002) as independent risk factors predisposing to PD dementia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastornos del Conocimiento / Factor Neurotrófico Derivado del Encéfalo Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurosci Lett Año: 2014 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastornos del Conocimiento / Factor Neurotrófico Derivado del Encéfalo Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurosci Lett Año: 2014 Tipo del documento: Article Pais de publicación: Irlanda