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Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.
Mehra, Rohit; Vats, Pankaj; Kalyana-Sundaram, Shanker; Udager, Aaron M; Roh, Michael; Alva, Ajjai; Pan, Jincheng; Lonigro, Robert J; Siddiqui, Javed; Weizer, Alon; Lee, Cheryl; Cao, Xuhong; Wu, Yi-Mi; Robinson, Dan R; Dhanasekaran, Saravana M; Chinnaiyan, Arul M.
Afiliación
  • Mehra R; Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan. Electronic address: mrohit@med.umich.edu.
  • Vats P; Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Kalyana-Sundaram S; Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Udager AM; Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan.
  • Roh M; Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan.
  • Alva A; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, Michigan; Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.
  • Pan J; Michigan Center for Translational Pathology, Ann Arbor, Michigan; Department of Urology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Lonigro RJ; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Siddiqui J; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Weizer A; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, Michigan; Department of Urology, University of Michigan Health System, Ann Arbor, Michigan.
  • Lee C; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, Michigan; Department of Urology, University of Michigan Health System, Ann Arbor, Michigan.
  • Cao X; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Wu YM; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Robinson DR; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Dhanasekaran SM; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
  • Chinnaiyan AM; Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, Michigan; Michigan Center for Translational Pathology, Ann Arbor, Michigan; Department of Urology, University of Michigan Health System, A
Am J Pathol ; 184(3): 584-91, 2014 Mar.
Article en En | MEDLINE | ID: mdl-24389164
Primary clear-cell adenocarcinoma of the urethra, a rare tumor that histomorphologically resembles clear-cell carcinoma of the female genital tract, occurs predominantly in women and is associated with a relatively poor prognosis. The histogenesis of this rare urethral neoplasm has not been completely resolved, but it is thought to arise from either müllerian rests or metaplastic urothelium. Herein, we present comprehensive surgical pathological and cytopathological findings from a patient with primary urethral clear-cell adenocarcinoma and describe next-generation sequencing results for this patient's unique tumor-the first such reported characterization of molecular aberrations in urethral clear-cell adenocarcinoma at the transcriptomic and genomic levels. Transcriptome analysis revealed novel gene fusion candidates, including ANKRD28-FNDC3B. Whole-exome analysis demonstrated focal copy number loss at the SMAD4 and ARID2 loci and 38 somatic mutations, including a truncating mutation in ATM and a novel nonsynonymous mutation in ALK.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Uretrales / Biomarcadores de Tumor / Adenocarcinoma de Células Claras Tipo de estudio: Prognostic_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Am J Pathol Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Uretrales / Biomarcadores de Tumor / Adenocarcinoma de Células Claras Tipo de estudio: Prognostic_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Am J Pathol Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos