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EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts.
Paixão, Sónia; Balijepalli, Aarathi; Serradj, Najet; Niu, Jingwen; Luo, Wenqin; Martin, John H; Klein, Rüdiger.
Afiliación
  • Paixão S; Department 'Molecules - Signals - Development,' Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany.
  • Balijepalli A; Department 'Molecules - Signals - Development,' Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany.
  • Serradj N; Department of Physiology, Pharmacology, and Neuroscience, City College of the City University of New York, New York, NY 10031, USA.
  • Niu J; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Luo W; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Martin JH; Department of Physiology, Pharmacology, and Neuroscience, City College of the City University of New York, New York, NY 10031, USA.
  • Klein R; Department 'Molecules - Signals - Development,' Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany; Munich Cluster for Systems Neurology (Synergy), 80336 Munich, Germany. Electronic address: rklein@neuro.mpg.de.
Neuron ; 80(6): 1407-20, 2013 Dec 18.
Article en En | MEDLINE | ID: mdl-24360544
The spinal cord contains many descending and ascending longitudinal tracts whose development appears to be controlled by distinct guidance systems. We identified a population of dorsal spinal neurons marked by coexpression of the transcription factor Zic2 and the guidance receptor EphA4. Zic2+;EphA4+ neurons are surrounded by mechanosensory terminals, suggesting innervation by mechanoreceptor afferents. Their axons form an ipsilateral ascending pathway that develops during embryogenesis and projects within the ventral aspect of the dorsal funiculus, the same location as the descending corticospinal tract (CST), which develops postnatally. Interestingly, the same guidance mechanism, namely, ephrinB3-induced EphA4 forward signaling, is required for the guidance of both ascending and descending axon tracts. Our analysis of conditional EphA4 mutant mice also revealed that the development of the dorsal funiculus occurs independently of EphA4 expression in descending CST axons and is linked to the distribution of Zic2+;EphA4+ spinal neurons and the formation of the ascending pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Espinal / Sistema Nervioso Central / Células del Asta Posterior / Receptor EphA4 / Efrina-B3 Tipo de estudio: Guideline / Prognostic_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2013 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Espinal / Sistema Nervioso Central / Células del Asta Posterior / Receptor EphA4 / Efrina-B3 Tipo de estudio: Guideline / Prognostic_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2013 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos