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MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse.
Feuermann, Yonatan; Kang, Keunsoo; Gavrilova, Oksana; Haetscher, Nadine; Jang, Seung Jin; Yoo, Kyung Hyun; Jiang, Changtao; Gonzalez, Frank J; Robinson, Gertraud W; Hennighausen, Lothar.
Afiliación
  • Feuermann Y; Laboratory of Genetics and Physiology; NIDDK, NIH; Bethesda, MD USA.
  • Kang K; Laboratory of Genetics and Physiology; NIDDK, NIH; Bethesda, MD USA.
  • Gavrilova O; Mouse Metabolic Core; NIDDK, NIH; Bethesda, MD USA.
  • Haetscher N; Laboratory of Genetics and Physiology; NIDDK, NIH; Bethesda, MD USA; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy and LOEWE Center for Cell and Gene Therapy Frankfurt and Department of Hematology/Oncology; Goethe University; Frankfurt am Main, Germany.
  • Jang SJ; Laboratory of Genetics and Physiology; NIDDK, NIH; Bethesda, MD USA.
  • Yoo KH; Laboratory of Metabolism, Center for Cancer Research, NCI; NIH; Bethesda, MD USA.
  • Jiang C; Laboratory of Metabolism, Center for Cancer Research, NCI; NIH; Bethesda, MD USA.
  • Gonzalez FJ; Laboratory of Genetics and Physiology; NIDDK, NIH; Bethesda, MD USA.
  • Robinson GW; Laboratory of Genetics and Physiology; NIDDK, NIH; Bethesda, MD USA.
  • Hennighausen L; Laboratory of Genetics and Physiology; NIDDK, NIH; Bethesda, MD USA.
RNA Biol ; 10(12): 1807-14, 2013 Dec.
Article en En | MEDLINE | ID: mdl-24356587
Generating heat and maintaining body temperature is the primary function of brown adipose tissue (BAT). Previous studies have implicated microRNAs, including miR-193b and miR-365-1, in BAT differentiation. We used mouse genetics to further understand the specific contributions of these two miRs. BAT function in mice with an inactivated miR-193b-365-1 locus, as determined by their response to the selective ß3 adrenergic receptor agonist CL316.243 and their tolerance to cold exposure, was normal and expression of genes associated with functional BAT, including Prdm16 and Ucp1, was unaffected. In addition, genome-wide expression profiles of miRNAs and mRNAs in BAT in the presence and absence of miR-193b-365-1 were determined. In summary, these data demonstrate, in contrast to earlier work, that the development, differentiation, and function of BAT do not require the presence of miR-193b and miR-365-1.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Pardo / MicroARNs Límite: Animals Idioma: En Revista: RNA Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2013 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Pardo / MicroARNs Límite: Animals Idioma: En Revista: RNA Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2013 Tipo del documento: Article Pais de publicación: Estados Unidos