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Investigation of decision-making under uncertainty in healthy subjects: a multi-centric fMRI study.
Krug, A; Cabanis, M; Pyka, M; Pauly, K; Walter, H; Landsberg, M; Shah, N Jon; Winterer, G; Wölwer, W; Musso, F; Müller, B W; Wiedemann, G; Herrlich, J; Schnell, K; Vogeley, K; Schilbach, L; Langohr, K; Rapp, A; Klingberg, S; Kircher, T.
Afiliación
  • Krug A; Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany. Electronic address: kruga@med.uni-marburg.de.
  • Cabanis M; Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.
  • Pyka M; Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.
  • Pauly K; Department of Psychiatry Psychotherapy, and Psychosomatic Medicine, Medical School, RWTH Aachen University, Aachen, Germany.
  • Walter H; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Berlin, Germany.
  • Landsberg M; Department of Medical Psychology, Rhineland Friedrich Wilhelms University, Bonn, Germany.
  • Shah NJ; Institute of Neuroscience and Biophysics 3 - Medicine, Research Center Jülich, Germany.
  • Winterer G; Cologne Center for Genomics, University of Cologne, Köln, Germany.
  • Wölwer W; Department of Psychiatry and Psychotherapy, Heinrich Heine University, Rhineland State Clinics for Psychiatry, Düsseldorf, Germany.
  • Musso F; Department of Psychiatry and Psychotherapy, Heinrich Heine University, Rhineland State Clinics for Psychiatry, Düsseldorf, Germany.
  • Müller BW; LVR-Hospital Essen, Department for Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, Germany.
  • Wiedemann G; Clinic of Psychiatry and Psychotherapy, Clinical Center, Fulda, Germany.
  • Herrlich J; Department of Psychiatry and Psychotherapy, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.
  • Schnell K; Department of General Psychiatry, University Hospital of Heidelberg, Heidelberg, Germany.
  • Vogeley K; Department of Psychiatry and Psychotherapy, University of Cologne, Köln, Germany; Institute for Neurosciences and Medicine, Cognitive Neuroscience (INM3), Research Center Jülich, Germany.
  • Schilbach L; Department of Psychiatry and Psychotherapy, University of Cologne, Köln, Germany.
  • Langohr K; Department of Psychiatry and Psychotherapy, Eberhard Karls University, Tübingen, Germany.
  • Rapp A; Department of Psychiatry and Psychotherapy, Eberhard Karls University, Tübingen, Germany.
  • Klingberg S; Department of Psychiatry and Psychotherapy, Eberhard Karls University, Tübingen, Germany.
  • Kircher T; Department of Psychiatry and Psychotherapy, Philipps-University, Marburg, Germany.
Behav Brain Res ; 261: 89-96, 2014 Mar 15.
Article en En | MEDLINE | ID: mdl-24355752
Decision-making is an everyday routine that entails several subprocesses. Decisions under uncertainty occur when either prior information is incomplete or the outcomes of the decision are unclear. The aim of the present study was to disentangle the neural correlates of information gathering as well as reaching a decision and to explore effects of uncertainty acceptance or avoidance in a large sample of healthy subjects. Sixty-four healthy volunteers performed a decision-making under uncertainty task in a multi-center approach while BOLD signal was measured with fMRI. Subjects either had to indicate via button press from which of two bottles red or blue balls were drawn (decision-making under uncertainty condition), or they had to indicate whether 8 red balls had been presented (baseline condition). During the information gathering phase (contrasted against the counting phase) a widespread network was found encompassing (pre-)frontal, inferior temporal and inferior parietal cortices. Reaching a decision was correlated with activations in the medial frontal cortex as well as the posterior cingulate and the precuneus. Effects of uncertainty acceptance were found within a network comprising of the superior frontal cortex as well as the insula and precuneus while uncertainty avoidance was correlated with activations in the right middle frontal cortex. The results depict two distinct networks for information gathering and the indication of having made a decision. While information-gathering networks are modulated by uncertainty avoidance and - acceptance, underlying networks of the decision itself are independent of these factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Toma de Decisiones / Incertidumbre Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Behav Brain Res Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Toma de Decisiones / Incertidumbre Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Behav Brain Res Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos