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Whole-body CT for lymphoma staging: feasibility of halving radiation dose and risk by iterative image reconstruction.
Meyer, M; Klein, S A; Brix, G; Fink, C; Pilz, L; Jafarov, H; Hofmann, W K; Schoenberg, S O; Henzler, T.
Afiliación
  • Meyer M; Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. Electronic address: mathias.meyer@medma.uni-heidelberg.de.
  • Klein SA; Department of Hematology and Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. Electronic address: stefan.klein@umm.de.
  • Brix G; Department of Medical and Occupational Radiation Protection, Federal Office for Radiation Protection, Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany. Electronic address: gbrix@bfs.de.
  • Fink C; Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. Electronic address: Christian.Fink@medma.uni-heidelberg.de.
  • Pilz L; Department of Biostatistics, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. Electronic address: lothar.pilz@medma.uni-heidelberg.de.
  • Jafarov H; Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. Electronic address: Hashim.Jafarov@umm.de.
  • Hofmann WK; Department of Hematology and Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. Electronic address: w.k.hofmann@umm.de.
  • Schoenberg SO; Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. Electronic address: Stefan.Schoenberg@umm.de.
  • Henzler T; Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany. Electronic address: thomas.henzler@medma.uni-heidelberg.de.
Eur J Radiol ; 83(2): 315-21, 2014 Feb.
Article en En | MEDLINE | ID: mdl-24355659
OBJECTIVES: Patients with lymphoma are at higher-risk of secondary malignancies mainly due to effects of cancer therapy as well as frequent radiological surveillance. We thus aimed to investigate the objective and subjective image quality as well as radiation exposure and risk of full-dose standard (FDS), full-dose iterative (FDI), and half-dose iterative (HDI) image reconstruction in patients with lymphoma. MATERIAL AND METHODS: In 100 lymphoma patients, contrast-enhanced whole-body staging was performed on a dual-source CT. To acquire full-dose and half-dose CT data simultaneously, the total current-time product was equally distributed on both tubes operating at 120 kV. HDI reconstructions were calculated by using only data from one tube. Quantitative image quality was assessed by measuring image noise in different tissues of the neck, thorax, and abdomen. Overall diagnostic image quality was assessed using a 5-point Likert scale. Radiation doses and risks were estimated for a male and female reference person. RESULTS: For all anatomical regions apart from the lungs image noise was significantly lower and the overall subjective image quality significantly better when using FDI and HDI instead of FDS reconstruction (p<0.05). For the half-dose protocol, the risk to develop a radiation-induced cancer was estimated to be less than 0.11/0.19% for an adult male/female. CONCLUSIONS: Image quality of FDI and more importantly of HDI is superior to FDS reconstruction, thus enabling to halve radiation dose and risk to lymphoma patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dosis de Radiación / Protección Radiológica / Interpretación de Imagen Radiográfica Asistida por Computador / Tomografía Computarizada por Rayos X / Imagen de Cuerpo Entero / Linfoma Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Radiol Año: 2014 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dosis de Radiación / Protección Radiológica / Interpretación de Imagen Radiográfica Asistida por Computador / Tomografía Computarizada por Rayos X / Imagen de Cuerpo Entero / Linfoma Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Radiol Año: 2014 Tipo del documento: Article Pais de publicación: Irlanda