Dioxatricyclic and oxabicyclic polyketides from Trichocladium opacum.
J Nat Prod
; 77(1): 9-14, 2014 Jan 24.
Article
en En
| MEDLINE
| ID: mdl-24354429
Five new polyketides, trichocladinols D-H (1-5) with dioxatricyclic (1-3) and oxabicyclic (4 and 5) skeletons, and the known massarilactone C (6) were isolated from the solid-substrate fermentation cultures of the ascomycete fungus Trichocladium opacum. The structures of 1-5 were determined mainly by NMR experiments, and 1, 3, and 4 were confirmed by X-ray crystallography. The absolute configurations of 1 and 3 were assigned by X-ray crystallography using Cu Kα radiation, whereas that of C-5 in 2 and 4 was deduced via the circular dichroism (CD) data. Compounds 2-4 showed weak cytotoxicity against the human tumor cell lines A549, HCT116, and SW480.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ascomicetos
/
Compuestos Heterocíclicos de Anillo en Puente
/
Policétidos
/
Antineoplásicos
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Estados Unidos