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Corticosteroids for dengue - why don't they work?
Nguyen, Thi Hanh Tien; Nguyen, Than Ha Quyen; Vu, Tuan Trung; Farrar, Jeremy; Hoang, Truong Long; Dong, Thi Hoai Tam; Ngoc Tran, Van; Phung, Khanh Lam; Wolbers, Marcel; Whitehead, Stephen S; Hibberd, Martin L; Wills, Bridget; Simmons, Cameron P.
Afiliación
  • Nguyen TH; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.
  • Nguyen TH; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.
  • Vu TT; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.
  • Farrar J; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam ; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Hoang TL; Genome Institute of Singapore, Singapore.
  • Dong TH; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.
  • Ngoc Tran V; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.
  • Phung KL; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.
  • Wolbers M; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam ; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Whitehead SS; Laboratory of Infectious Diseases (LID), National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America.
  • Hibberd ML; Genome Institute of Singapore, Singapore.
  • Wills B; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam ; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Simmons CP; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam ; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom ; Nossal Institute of Global Health, School of Population and Global Health, University o
PLoS Negl Trop Dis ; 7(12): e2592, 2013.
Article en En | MEDLINE | ID: mdl-24349598
BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels. CONCLUSION: The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prednisolona / Dengue / Factores Inmunológicos Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2013 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prednisolona / Dengue / Factores Inmunológicos Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2013 Tipo del documento: Article Pais de publicación: Estados Unidos