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The effect of Chinese medicine Pu-Ren-Dan on pancreatic angiogenesis in high fat diet/streptozotocin-induced diabetic rats.
Lu, Binan; Bai, Yongfei; Du, Ziliang; Chen, Shu; Deligema, D; Pang, Zongran.
Afiliación
  • Lu B; Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, P. R. China.
  • Bai Y; Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, P. R. China.
  • Du Z; Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, P. R. China.
  • Chen S; Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, P. R. China.
  • Deligema D; Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, P. R. China.
  • Pang Z; Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, P. R. China.
Indian J Pharmacol ; 45(6): 556-62, 2013.
Article en En | MEDLINE | ID: mdl-24347761
OBJECTIVES: The islet vascular system is critical for ß-cell function. This study investigated the antidiabetic effect of the Chinese Pu-Ren-Dan (PRD) recipe by regulating the pancreatic angiogenic factors in T2DM rats. MATERIALS METHODS: High fat diet/streptozotocin-induced obese type-2 diabetes mellitus rats were developed and treated with PRD for 4 weeks. Then glucolipid metabolism, insulin secretion, pancreatic blood flow, ultrastructure of islet ß-cell, histological changes of islet and protein expressions of pancreatic angiogenic factors were investigated. RESULTS: PRD-reduced T2DM rats' body weight and blood glucose level resisted the lipid metabolism disturbance, and ameliorated the insulin resistance and ß-cell function. In addition, the histological and morphological studies proved that PRD could maintain the normal distribution of endocrine cell in islet and normal ultrastructure of ß cell. An increased pancreatic blood flow was observed after the PRD treatment. In the investigation of pancreatic angiogenic factors, PRD inhibited the decreased expression of VEGF and Ang-1, and reversed the reduction of VEGFR2 and Tie2 phosphorylation in T2DM rats; the Ang-2 and TGFß expression were up-regulated by PRD while PKC was activated; endostatin and angiostatin were down-regulated by PRD. CONCLUSIONS: The results suggest that increasing VEGF expression, regulating VEGF/VEGFR2 signaling, stimulating Ang-1/Tie-2 signaling pathway, and inhibiting PKC-TGFß signaling and antiangiogenic factors might be the underlying mechanism of PRD's antidiabetic effect.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Dieta Alta en Grasa / Neovascularización Patológica Límite: Animals Idioma: En Revista: Indian J Pharmacol Año: 2013 Tipo del documento: Article Pais de publicación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Dieta Alta en Grasa / Neovascularización Patológica Límite: Animals Idioma: En Revista: Indian J Pharmacol Año: 2013 Tipo del documento: Article Pais de publicación: India