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Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in ß cells.
Tornovsky-Babeay, Sharona; Dadon, Daniela; Ziv, Oren; Tzipilevich, Elhanan; Kadosh, Tehila; Schyr-Ben Haroush, Rachel; Hija, Ayat; Stolovich-Rain, Miri; Furth-Lavi, Judith; Granot, Zvi; Porat, Shay; Philipson, Louis H; Herold, Kevan C; Bhatti, Tricia R; Stanley, Charles; Ashcroft, Frances M; In't Veld, Peter; Saada, Ann; Magnuson, Mark A; Glaser, Benjamin; Dor, Yuval.
Afiliación
  • Tornovsky-Babeay S; Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
  • Dadon D; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Ziv O; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Tzipilevich E; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Kadosh T; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Schyr-Ben Haroush R; Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusal
  • Hija A; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Stolovich-Rain M; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Furth-Lavi J; Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
  • Granot Z; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
  • Porat S; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel; Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem 91240, Israel
  • Philipson LH; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA.
  • Herold KC; Departments of Immunobiology and Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
  • Bhatti TR; Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Stanley C; Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Ashcroft FM; Department of Physiology, Anatomy & Genetics, Oxford University, Oxford OX1 3QX, UK.
  • In't Veld P; Diabetes Research Center, Brussels Free University, Laarbeeklaan 103, B1090 Brussels, Belgium.
  • Saada A; Monique and Jacques Roboh Department of Genetic Research and the Department of Genetics and Metabolic Diseases, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
  • Magnuson MA; Center for Stem Cell Biology and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Glaser B; Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel. Electronic address: beng@cc.huji.ac.il.
  • Dor Y; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address: yuvald@ekmd.huji.ac.il.
Cell Metab ; 19(1): 109-21, 2014 Jan 07.
Article en En | MEDLINE | ID: mdl-24332968
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Hiperinsulinismo Congénito / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Roturas del ADN de Doble Cadena Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2014 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Hiperinsulinismo Congénito / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Roturas del ADN de Doble Cadena Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2014 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos