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PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.
Maréchal, Alexandre; Li, Ju-Mei; Ji, Xiao Ye; Wu, Ching-Shyi; Yazinski, Stephanie A; Nguyen, Hai Dang; Liu, Shizhou; Jiménez, Amanda E; Jin, Jianping; Zou, Lee.
Afiliación
  • Maréchal A; Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown, MA 02129.
  • Li JM; Department of Biochemistry and Molecular Biology The University of Texas Health Science Center at Houston Houston, TX 77030.
  • Ji XY; Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown, MA 02129.
  • Wu CS; Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown, MA 02129.
  • Yazinski SA; Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown, MA 02129.
  • Nguyen HD; Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown, MA 02129.
  • Liu S; Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown, MA 02129.
  • Jiménez AE; Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown, MA 02129.
  • Jin J; Department of Biochemistry and Molecular Biology The University of Texas Health Science Center at Houston Houston, TX 77030.
  • Zou L; Massachusetts General Hospital Cancer Center Harvard Medical School Charlestown, MA 02129.
Mol Cell ; 53(2): 235-246, 2014 Jan 23.
Article en En | MEDLINE | ID: mdl-24332808

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / ADN de Cadena Simple / Proteínas Nucleares / Ubiquitina / Enzimas Reparadoras del ADN / Proteína de Replicación A Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / ADN de Cadena Simple / Proteínas Nucleares / Ubiquitina / Enzimas Reparadoras del ADN / Proteína de Replicación A Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos