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Correlation between chemotype-dependent binding conformations of HSP90α/ß and isoform selectivity-Implications for the structure-based design of HSP90α/ß selective inhibitors for treating neurodegenerative diseases.
Ernst, Justin T; Liu, Michael; Zuccola, Harmon; Neubert, Timothy; Beaumont, Kevin; Turnbull, Amy; Kallel, Adam; Vought, Bryan; Stamos, Dean.
Afiliación
  • Ernst JT; Vertex Pharmaceuticals, Department of Chemistry and Drug Innovation, 11010 Torreyana Road, San Diego, CA 92121, United States. Electronic address: Justin_Ernst@vrtx.com.
  • Liu M; Vertex Pharmaceuticals, Department of Biology, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Zuccola H; Vertex Pharmaceuticals, Department of Protein Sciences, 130 Waverly Street, Cambridge, MA 02139, United States.
  • Neubert T; Vertex Pharmaceuticals, Department of Chemistry and Drug Innovation, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Beaumont K; Vertex Pharmaceuticals, Department of Biology, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Turnbull A; Vertex Pharmaceuticals, Department of Biology, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Kallel A; Vertex Pharmaceuticals, Department of Chemistry and Drug Innovation, 11010 Torreyana Road, San Diego, CA 92121, United States.
  • Vought B; Vertex Pharmaceuticals, Department of Protein Sciences, 130 Waverly Street, Cambridge, MA 02139, United States.
  • Stamos D; Vertex Pharmaceuticals, Department of Chemistry and Drug Innovation, 11010 Torreyana Road, San Diego, CA 92121, United States.
Bioorg Med Chem Lett ; 24(1): 204-8, 2014 Jan 01.
Article en En | MEDLINE | ID: mdl-24332488
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Proteínas HSP90 de Choque Térmico / Enfermedades Neurodegenerativas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Proteínas HSP90 de Choque Térmico / Enfermedades Neurodegenerativas Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido