Synthesis, anti-HIV activity, integrase enzyme inhibition and molecular modeling of catechol, hydroquinone and quinol labdane analogs.

Pawar, Rohan; Das, Tiyasa; Mishra, Sanjay; Pancholi, Boskey; Gupta, Satish K; Bhat, Sujata V

Pawar, Rohan; Das, Tiyasa; Mishra, Sanjay; Pancholi, Boskey; Gupta, Satish K; Bhat, Sujata V.

Afiliación

Pawar R; Laboratory for Advanced Research in Natural and Synthetic Chemistry, V.G. Vaze College, Mumbai University, Mithagar Road, Mulund (East), Mumbai 400 081, India.
Das T; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India.
Mishra S; Laboratory for Advanced Research in Natural and Synthetic Chemistry, V.G. Vaze College, Mumbai University, Mithagar Road, Mulund (East), Mumbai 400 081, India.
Nutan; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India.
Pancholi B; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India.
Gupta SK; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India. Electronic address: skgupta@nii.ac.in.
Bhat SV; Laboratory for Advanced Research in Natural and Synthetic Chemistry, V.G. Vaze College, Mumbai University, Mithagar Road, Mulund (East), Mumbai 400 081, India. Electronic address: sujata8b@gmail.com.

Bioorg Med Chem Lett ; 24(1): 302-7, 2014 Jan 01.

Article en En | MEDLINE | ID: mdl-24291042

Asunto(s)

Fármacos Anti-VIH/farmacología; Catecoles/farmacología; Inhibidores de Integrasa VIH/farmacología; Integrasa de VIH/metabolismo; VIH/efectos de los fármacos; Hidroquinonas/farmacología; Fármacos Anti-VIH/síntesis química; Fármacos Anti-VIH/química; Catecoles/síntesis química; Catecoles/química; Relación Dosis-Respuesta a Droga; VIH/enzimología; Inhibidores de Integrasa VIH/síntesis química; Inhibidores de Integrasa VIH/química; Hidroquinonas/síntesis química; Hidroquinonas/química; Pruebas de Sensibilidad Microbiana; Modelos Moleculares; Estructura Molecular; Relación Estructura-Actividad

Palabras clave

3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide; ACN; Anti-HIV-1 activity; Computational study; DielsAlder reaction; HIV-1 integrase inhibition; IBD; IN CCD; Labdane analogs; MTT; RT; TI; acetonitrile; integrase catalytic core domain; iodoso benzene diacetate; o-Quinolcatecholhydroquinone moiety; room temperature; therapeutic index

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catecoles / VIH / Inhibidores de Integrasa VIH / Integrasa de VIH / Fármacos Anti-VIH / Hidroquinonas Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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