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Gait analysis in a pre- and post-ischemic stroke biomedical pig model.
Duberstein, Kylee Jo; Platt, Simon R; Holmes, Shannon P; Dove, C Robert; Howerth, Elizabeth W; Kent, Marc; Stice, Steven L; Hill, William D; Hess, David C; West, Franklin D.
Afiliación
  • Duberstein KJ; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.
  • Platt SR; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA; Department of Small Animal and Surgery, University of Georgia, Athens, GA 30602, USA.
  • Holmes SP; Department of Veterinary Biosciences & Diagnostic Imaging, University of Georgia, Athens, GA 30602, USA.
  • Dove CR; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.
  • Howerth EW; Department of Pathology, University of Georgia, Athens, GA 30602, USA.
  • Kent M; Department of Small Animal and Surgery, University of Georgia, Athens, GA 30602, USA.
  • Stice SL; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA.
  • Hill WD; Department of Neurology, Georgia Regents University, Augusta, GA 30912, USA; Department of Cellular Biology & Anatomy, Georgia Regents University, Augusta, GA 30912, USA.
  • Hess DC; Department of Neurology, Georgia Regents University, Augusta, GA 30912, USA.
  • West FD; Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, USA; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA. Electronic address: westf@uga.edu.
Physiol Behav ; 125: 8-16, 2014 Feb 10.
Article en En | MEDLINE | ID: mdl-24286894
Severity of neural injury including stroke in human patients, as well as recovery from injury, can be assessed through changes in gait patterns of affected individuals. Similar quantification of motor function deficits has been measured in rodent animal models of such injuries. However, due to differences in fundamental structure of human and rodent brains, there is a need to develop a large animal model to facilitate treatment development for neurological conditions. Porcine brain structure is similar to that of humans, and therefore the pig may make a more clinically relevant animal model. The current study was undertaken to determine key gait characteristics in normal biomedical miniature pigs and dynamic changes that occur post-neural injury in a porcine middle cerebral artery (MCA) occlusion ischemic stroke model. Yucatan miniature pigs were trained to walk through a semi-circular track and were recorded with high speed cameras to detect changes in key gait parameters. Analysis of normal pigs showed overall symmetry in hindlimb swing and stance times, forelimb stance time, along with step length, step velocity, and maximum hoof height on both fore and hindlimbs. A subset of pigs were again recorded at 7, 5 and 3 days prior to MCA occlusion and then at 1, 3, 5, 7, 14 and 30 days following surgery. MRI analysis showed that MCA occlusion resulted in significant infarction. Gait analysis indicated that stroke resulted in notable asymmetries in both temporal and spatial variables. Pigs exhibited lower maximum front hoof height on the paretic side, as well as shorter swing time and longer stance time on the paretic hindlimb. These results support that gait analysis of stroke injury is a highly sensitive detection method for changes in gait parameters in pig.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Porcinos / Isquemia Encefálica / Accidente Cerebrovascular / Trastornos Neurológicos de la Marcha / Modelos Animales de Enfermedad / Marcha Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Physiol Behav Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Porcinos / Isquemia Encefálica / Accidente Cerebrovascular / Trastornos Neurológicos de la Marcha / Modelos Animales de Enfermedad / Marcha Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Physiol Behav Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos