The impact of pre-analytical variables on the stability of neurofilament proteins in CSF, determined by a novel validated SinglePlex Luminex assay and ELISA.

Koel-Simmelink, Marleen J A; Vennegoor, Anke; Killestein, Joep; Blankenstein, Marinus A; Norgren, Niklas; Korth, Carsten; Teunissen, Charlotte E

Koel-Simmelink, Marleen J A; Vennegoor, Anke; Killestein, Joep; Blankenstein, Marinus A; Norgren, Niklas; Korth, Carsten; Teunissen, Charlotte E.

Afiliación

Koel-Simmelink MJ; Department of Clinical Chemistry, VU University Medical Center Amsterdam, PO Box 7057, 1007MB Amsterdam, The Netherlands. Electronic address: mja.koel-simmelink@vumc.nl.
Vennegoor A; Department of Neurology, VU University Medical Center Amsterdam, PO Box 7057, 1007MB Amsterdam. The Netherlands. Electronic address: a.vennegoor@vumc.nl.
Killestein J; Department of Neurology, VU University Medical Center Amsterdam, PO Box 7057, 1007MB Amsterdam. The Netherlands. Electronic address: j.killestein@vumc.nl.
Blankenstein MA; Department of Clinical Chemistry, VU University Medical Center Amsterdam, PO Box 7057, 1007MB Amsterdam, The Netherlands. Electronic address: ma.blankenstein@vumc.nl.
Norgren N; UmanDiagnostics, PO Box 7996, 90719 Umeå, Sweden. Electronic address: niklas.norgren@umandiagnostics.se.
Korth C; Neurodegeneration Unit, Department Neuropathology, University of Düsseldorf Medical School, Moorenstrase 5, 40225 Düsseldorf, Germany. Electronic address: ckorth@uni-duesseldorf.de.
Teunissen CE; Department of Clinical Chemistry, VU University Medical Center Amsterdam, PO Box 7057, 1007MB Amsterdam, The Netherlands. Electronic address: c.teunissen@vumc.nl.

J Immunol Methods ; 402(1-2): 43-9, 2014 Jan 15.

Article en En | MEDLINE | ID: mdl-24275679

Asunto(s)

Ensayo de Inmunoadsorción Enzimática; Proteínas de Neurofilamentos/líquido cefalorraquídeo; Biomarcadores/líquido cefalorraquídeo; Congelación; Humanos; Proteínas de Neurofilamentos/sangre; Variaciones Dependientes del Observador; Estabilidad Proteica; Reproducibilidad de los Resultados; Temperatura; Factores de Tiempo

Palabras clave

AD; ALS; Alzheimer disease; CIS; CSF; Cerebrospinal fluid; ELISA; Enzyme Linked Immuno Sorbent Assay; FTD; HQC; LBD; LOD; LOL; LP; LQC; Lewy bodies disease; Limit of linearity; MS; Neurofilament heavy (NfH) protein; Neurofilament light (NfL) protein; Nf; NfH; NfH SinglePlex Luminex assay; NfL; Pre-analytical variables; SD; Stability; amyotrophic lateral sclerosis; cerebrospinal fluid; clinically isolated syndrome; frontotemporal dementia; high quality control; limit of detection; low quality control; lumbar puncture; multiple sclerosis; neurofilament; neurofilament heavy; neurofilament light; standard deviation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayo de Inmunoadsorción Enzimática / Proteínas de Neurofilamentos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Immunol Methods Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos

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