Lantabetulic acid derivatives induce G1 arrest and apoptosis in human prostate cancer cells.
Arch Pharm (Weinheim)
; 347(1): 42-53, 2014 Jan.
Article
en En
| MEDLINE
| ID: mdl-24243582
Ten new lantabetulic acid (1) derivatives 2-11 were synthesized and their cytotoxicities against human prostate cancer cells were evaluated. PC3 cells treated with 10 µM 8 exhibited the most potent G1 phase arrest. In addition, 10 µM 8 markedly decreased the levels of cyclin E and cdk2 and caused an increase in the p21 and p27 levels, while 20 µM 8 mainly led to cell death through the apoptotic pathway, which correlated with an increase in reactive oxygen species levels, decreased expression levels of Bcl-2 and caspase-8, the induction of mitochondrial changes, and decreased levels of cytochrome c in mitochondria. The dual action of 8 could provide a new approach for the development of chemotherapeutic drugs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Triterpenos
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Apoptosis
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Puntos de Control de la Fase G1 del Ciclo Celular
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Antineoplásicos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Arch Pharm (Weinheim)
Año:
2014
Tipo del documento:
Article
País de afiliación:
Taiwán
Pais de publicación:
Alemania