Galanin: evidence for a hypothalamic site of action to release growth hormone.
Peptides
; 7(1): 51-3, 1986.
Article
en En
| MEDLINE
| ID: mdl-2423991
Galanin is a 29 amino acid peptide that was isolated and characterized from porcine intestinal extracts. The presence of galanin-like immunoreactivity in neuronal elements in the hypothalamus and median eminence suggested a role for it in the hypothalamic control of anterior pituitary function. A hypothalamic site of action of galanin to stimulate growth hormone (GH) release is suggested by our observation that doses as low as 50 picomoles when infused into the third cerebroventricle of conscious, unrestrained ovariectomized rats resulted in significantly elevated plasma levels of GH. This effect was specific for GH and was dose-related. The failure of galanin to alter GH release from dispersed, cultured anterior pituitary cells in vitro further suggests that endogenous galanin plays a neuromodulatory role at the level of the median eminence, possibly affecting the release of known GH-releasing and/or inhibiting factors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Adenohipófisis
/
Hormona del Crecimiento
/
Sistema Hipotálamo-Hipofisario
Límite:
Animals
Idioma:
En
Revista:
Peptides
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Estados Unidos