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Diagnosis of neuroschistosomiasis by antibody specificity index and semi-quantitative real-time PCR from cerebrospinal fluid and serum.
Härter, Georg; Frickmann, Hagen; Zenk, Sebastian; Wichmann, Dominic; Ammann, Bettina; Kern, Peter; Fleischer, Bernhard; Tannich, Egbert; Poppert, Sven.
Afiliación
  • Härter G; Department of Infectious Diseases and Clinical Immunology, Comprehensive Infectious Diseases Centre Ulm and Clinic of Internal Medicine III, University Hospital Ulm, Germany.
  • Frickmann H; Institute for Microbiology, Virology and Hygiene, University Hospital Rostock, Germany.
  • Zenk S; Department of Tropical Medicine at the Bernhard Nocht Institute, German Armed Forces Hospital of Hamburg, Germany.
  • Wichmann D; Institute for Medical Microbiology and Hygiene, University Hospital Ulm, Germany.
  • Ammann B; Department of Intensive Care Medicine, University Hospital Eppendorf, Hamburg, Germany.
  • Kern P; Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Germany.
  • Fleischer B; Department of Infectious Diseases and Clinical Immunology, Comprehensive Infectious Diseases Centre Ulm and Clinic of Internal Medicine III, University Hospital Ulm, Germany.
  • Tannich E; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
  • Poppert S; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
J Med Microbiol ; 63(Pt 2): 309-312, 2014 Feb.
Article en En | MEDLINE | ID: mdl-24227876
We describe the case of a 16-year-old German male expatriate from Ghana who presented with obstipation, dysuria, dysaesthesia of the gluteal region and the lower limbs, bilateral plantar hypaesthesia and paraesthesia without pareses. A serum-cerebrospinal fluid (CSF) Schistosoma spp. specific antibody specificity index of 3.1 was considered highly suggestive of intrathecal synthesis of anti-Schistosoma spp. specific antibodies, although standardization of this procedure has not previously been described. Diagnosis was confirmed by detection of Schistosoma DNA in CSF by semi-quantitative real-time PCR at 100-fold concentration compared with serum. Accordingly the two diagnostic procedures, which have not previously been applied for routine diagnosis, appear to be useful for the diagnosis of neuroschistosomiasis. Clinical symptoms resolved following anthelmintic and anti-inflammatory therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Schistosoma / Anticuerpos Antihelmínticos / Neuroesquistosomiasis / Reacción en Cadena en Tiempo Real de la Polimerasa / Especificidad de Anticuerpos Tipo de estudio: Diagnostic_studies Límite: Adolescent / Animals / Humans / Male País/Región como asunto: Africa / Europa Idioma: En Revista: J Med Microbiol Año: 2014 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Schistosoma / Anticuerpos Antihelmínticos / Neuroesquistosomiasis / Reacción en Cadena en Tiempo Real de la Polimerasa / Especificidad de Anticuerpos Tipo de estudio: Diagnostic_studies Límite: Adolescent / Animals / Humans / Male País/Región como asunto: Africa / Europa Idioma: En Revista: J Med Microbiol Año: 2014 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido