An N-terminal pro-atrial natriuretic peptide (NT-proANP) 'aggregation-prone' segment involved in isolated atrial amyloidosis.

Louros, Nikolaos N; Iconomidou, Vassiliki A; Tsiolaki, Paraskevi L; Chrysina, Evangelia D; Baltatzis, Georgios E; Patsouris, Efstratios S; Hamodrakas, Stavros J

Louros, Nikolaos N; Iconomidou, Vassiliki A; Tsiolaki, Paraskevi L; Chrysina, Evangelia D; Baltatzis, Georgios E; Patsouris, Efstratios S; Hamodrakas, Stavros J.

Afiliación

Louros NN; Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 157 01, Greece.
Iconomidou VA; Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 157 01, Greece.
Tsiolaki PL; Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 157 01, Greece.
Chrysina ED; Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 116 35, Greece.
Baltatzis GE; 1st Department of Pathology, Medical School, University of Athens, 75 Mikras Assias, Goudi 115 27, Greece.
Patsouris ES; 1st Department of Pathology, Medical School, University of Athens, 75 Mikras Assias, Goudi 115 27, Greece.
Hamodrakas SJ; Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 157 01, Greece. Electronic address: shamodr@biol.uoa.gr.

FEBS Lett ; 588(1): 52-7, 2014 Jan 03.

Article en En | MEDLINE | ID: mdl-24220659

RESUMEN

Isolated atrial amyloidosis (IAA) is a common localized form of amyloid deposition within the atria of the aging heart. The main constituents of amyloid fibrils are atrial natriuretic peptide (ANP) and the N-terminal part of its precursor form (NT-proANP). An 'aggregation-prone' heptapeptide ((114)KLRALLT(120)) was located within the NT-proANP sequence. This peptide self-assembles into amyloid-like fibrils in vitro, as electron microscopy, X-ray fiber diffraction, ATR FT-IR spectroscopy and Congo red staining studies reveal. Consequently, remedies/drugs designed to inhibit the aggregation tendency of this 'aggregation-prone' segment of NT-proANP may assist in prevention/treatment of IAA, congestive heart failure (CHF) or atrial fibrillation (AF).

Asunto(s)

Amiloidosis/metabolismo; Factor Natriurético Atrial/metabolismo; Fragmentos de Péptidos/metabolismo; Precursores de Proteínas/metabolismo; Secuencia de Aminoácidos; Amiloide/química; Amiloide/metabolismo; Amiloide/ultraestructura; Factor Natriurético Atrial/química; Factor Natriurético Atrial/genética; Rojo Congo/química; Atrios Cardíacos/metabolismo; Atrios Cardíacos/patología; Humanos; Microscopía Electrónica; Datos de Secuencia Molecular; Fragmentos de Péptidos/química; Fragmentos de Péptidos/genética; Precursores de Proteínas/química; Precursores de Proteínas/genética; Espectroscopía Infrarroja por Transformada de Fourier; Difracción de Rayos X/métodos

Palabras clave

AF; ANP; ATR FT-IR spectroscopy; Amyloid fibril; BNP; CHF; Cardiac amyloidose; IAA; Isolated atrial amyloidosis (IAA); N-terminal pro-atrial natriuretic peptide; N-terminal pro-atrial natriuretic peptide (NT-proANP); NT-proANP; Natriuretic peptide; SSA; TTR; atrial fibrosis; atrial natriuretic peptide; attenuated total reflectance Fourier-transform spectroscopy; brain natriuretic peptide; cGMP; congestive heart failure; cyclic guanosine monophosphate; isolated atrial amyloidosis; senile systemic amyloidosis; transthyretin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Precursores de Proteínas / Factor Natriurético Atrial / Amiloidosis Límite: Humans Idioma: En Revista: FEBS Lett Año: 2014 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido

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