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Investigating the causal effect of vitamin D on serum adiponectin using a Mendelian randomization approach.
Husemoen, L L N; Skaaby, T; Martinussen, T; Jørgensen, T; Thuesen, B H; Kistorp, C; Jeppesen, J; Thyssen, J P; Meldgaard, M; Szecsi, P B; Fenger, M; Linneberg, A.
Afiliación
  • Husemoen LL; Research Centre for Prevention and Health, Copenhagen University Hospital Glostrup, Glostrup, Denmark.
  • Skaaby T; Research Centre for Prevention and Health, Copenhagen University Hospital Glostrup, Glostrup, Denmark.
  • Martinussen T; Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
  • Jørgensen T; 1] Research Centre for Prevention and Health, Copenhagen University Hospital Glostrup, Glostrup, Denmark [2] Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
  • Thuesen BH; Research Centre for Prevention and Health, Copenhagen University Hospital Glostrup, Glostrup, Denmark.
  • Kistorp C; Department of Cardiology and Endocrinology, Copenhagen University Hospital Frederiksberg, Frederiksberg, Denmark.
  • Jeppesen J; 1] Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark [2] Department of Medicine M, Copenhagen University Hospital Glostrup, Glostrup, Denmark.
  • Thyssen JP; National Allergy Research Centre, Department of Dermato Allergology, Copenhagen University Hospital Gentofte, Hellerup, Denmark.
  • Meldgaard M; Department of Clinical Biochemistry, Copenhagen University Hospital Gentofte, Hellerup, Denmark.
  • Szecsi PB; Department of Clinical Biochemistry, Copenhagen University Hospital Gentofte, Hellerup, Denmark.
  • Fenger M; Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
  • Linneberg A; Research Centre for Prevention and Health, Copenhagen University Hospital Glostrup, Glostrup, Denmark.
Eur J Clin Nutr ; 68(2): 189-95, 2014 Feb.
Article en En | MEDLINE | ID: mdl-24219894
BACKGROUND/OBJECTIVES: The aim was to examine the causal effect of vitamin D on serum adiponectin using a multiple instrument Mendelian randomization approach. SUBJECTS/METHODS: Serum 25-hydroxy vitamin D (25(OH)D) and serum total or high molecular weight (HMW) adiponectin were measured in two Danish population-based studies: the Inter99 study (6405 adults, 30-60 years) conducted in 1999-2001, and the MONICA10 study (2656 adults, 41-71 years) conducted in 1993-1994. RESULTS: In the Inter99 study, serum 25(OH)D was positively associated with total adiponectin (the effect estimate in % per doubling of 25(OH)D was 4.78, 95% CI: 1.96, 7.68, P<0.001). Using variations in the vitamin D-binding protein gene and the filaggrin gene as instrumental variables, the causal effect in % was estimated to 61.46, 95% CI: 17.51, 120.28, P=0.003 higher adiponectin per doubling of 25(OH)D. In the MONICA10 cohort, no significant association was observed between the serum concentrations of 25(OH)D and HMW adiponectin (the effect estimate in % per doubling of 25(OH)D was -1.51, 95% CI: -5.80, 2.98, P=0.50), although the instrumental variables analysis to some extent supported a positive causal association (the effect estimate in % per doubling of 25(OH)D was 37.13, 95% CI: -3.67, 95.20, P=0.080). CONCLUSIONS: The results indicate a possible causal association between serum 25(OH)D and total adiponectin. However, the association was not replicated for HMW adiponectin. Thus, further studies are needed to confirm a causal relationship.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Vitamina D / Adiponectina / Análisis de la Aleatorización Mendeliana Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2014 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Vitamina D / Adiponectina / Análisis de la Aleatorización Mendeliana Tipo de estudio: Clinical_trials Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2014 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido