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Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism.
Somm, Emmanuel; Larvaron, Pierre; van de Looij, Yohan; Toulotte, Audrey; Chatagner, Alexandra; Faure, Magali; Métairon, Sylviane; Mansourian, Robert; Raymond, Frédéric; Gruetter, Rolf; Wang, Bing; Sizonenko, Stéphane V; Hüppi, Petra S.
Afiliación
  • Somm E; Department of Paediatrics, Division of Development and Growth, University of Geneva School of Medicine, Geneva, Switzerland.
  • Larvaron P; Department of Paediatrics, Division of Development and Growth, University of Geneva School of Medicine, Geneva, Switzerland.
  • van de Looij Y; 1] Department of Paediatrics, Division of Development and Growth, University of Geneva School of Medicine, Geneva, Switzerland [2] Laboratory for Functional and Metabolic Imaging, E´cole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Toulotte A; Department of Paediatrics, Division of Development and Growth, University of Geneva School of Medicine, Geneva, Switzerland.
  • Chatagner A; Department of Paediatrics, Division of Development and Growth, University of Geneva School of Medicine, Geneva, Switzerland.
  • Faure M; Nestlé Research Center, Lausanne, Switzerland.
  • Métairon S; Nestlé Research Center, Lausanne, Switzerland.
  • Mansourian R; Nestlé Research Center, Lausanne, Switzerland.
  • Raymond F; Nestlé Research Center, Lausanne, Switzerland.
  • Gruetter R; Laboratory for Functional and Metabolic Imaging, E´cole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Wang B; 1] Nestlé Research Center, Lausanne, Switzerland [2] School of Animal and Veterinary Science, Charles Sturt University, New South Wales, Australia.
  • Sizonenko SV; Department of Paediatrics, Division of Development and Growth, University of Geneva School of Medicine, Geneva, Switzerland.
  • Hüppi PS; Department of Paediatrics, Division of Development and Growth, University of Geneva School of Medicine, Geneva, Switzerland.
Pediatr Res ; 75(1-1): 51-61, 2014 Jan.
Article en En | MEDLINE | ID: mdl-24213624
BACKGROUND: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementation with bLf on IUGR-induced sequelae, including inadequate growth and altered cerebral development, remains unknown. METHODS: IUGR was induced through maternal dexamethasone infusion (100 µg/kg during last gestational week) in rats. Maternal supplementation with bLf (0.85% in food pellet) was provided during both gestation and lactation. Pup growth was monitored, and Pup brain metabolism and gene expression were studied using in vivo (1)H NMR spectroscopy, quantitative PCR, and microarray in the hippocampus at postnatal day (PND)7. RESULTS: Maternal bLf supplementation did not change gestational weight but increased the birth body weight of control pups (4%) with no effect on the IUGR pups. Maternal bLf supplementation allowed IUGR pups to recover a normalized weight at PND21 (weaning) improving catch-up growth. Significantly altered levels of brain metabolites (γ-aminobutyric acid, glutamate, N-acetylaspartate, and N-acetylaspartylglutamate) and transcripts (brain-derived neurotrophic factor (BDNF), divalent metal transporter 1 (DMT-1), and glutamate receptors) in IUGR pups were normalized with maternal bLf supplementation. CONCLUSION: Our data suggest that maternal bLf supplementation is a beneficial nutritional intervention able to revert some of the IUGR-induced sequelae, including brain hippocampal changes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Suplementos Dietéticos / Crecimiento / Lactoferrina Tipo de estudio: Risk_factors_studies Límite: Animals / Pregnancy Idioma: En Revista: Pediatr Res Año: 2014 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Suplementos Dietéticos / Crecimiento / Lactoferrina Tipo de estudio: Risk_factors_studies Límite: Animals / Pregnancy Idioma: En Revista: Pediatr Res Año: 2014 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos