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Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells.
Ren, Xiao-Shuai; Yin, Meng-Hui; Zhang, Xin; Wang, Zhe; Feng, Shi-Peng; Wang, Guo-Xin; Luo, Ying-Jun; Liang, Pei-Zhou; Yang, Xiu-Qun; He, Jian-Xing; Zhang, Bi-Liang.
Afiliación
  • Ren XS; The State Key Laboratory of Respiratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Science and Technology of China, Hefei 230026, China.
  • Yin MH; The State Key Laboratory of Respiratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Science and Technology of China, Hefei 230026, China.
  • Zhang X; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
  • Wang Z; The State Key Laboratory of Respiratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
  • Feng SP; Guangzhou RiboBio Co., Ltd., Guangzhou 510663, China.
  • Wang GX; The State Key Laboratory of Respiratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
  • Luo YJ; Guangzhou RiboBio Co., Ltd., Guangzhou 510663, China.
  • Liang PZ; The State Key Laboratory of Respiratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Graduate University of Chinese Academy of Sciences, Beijing 100049, China.
  • Yang XQ; Guangzhou RiboBio Co., Ltd., Guangzhou 510663, China.
  • He JX; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China. Electronic address: drjianxing.he@gmail.com.
  • Zhang BL; The State Key Laboratory of Respiratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Science and Technology of China, Hefei 230026, China. Electronic address: zhang_biliang@gibh.org.
Cancer Lett ; 344(2): 195-203, 2014 Mar 28.
Article en En | MEDLINE | ID: mdl-24211326
MicroRNA-449a (miR-449a) was significantly downregulated in 156 lung cancer tissues (p<0.001). We found that the low expression of miR-449a was highly correlated with cancer recurrence and survival of lung cancer patients. The transient introduction of miR-449a caused cell cycle arrest and cell senescence in A549 and 95D cells. Further studies revealed that E2F3 was a direct target of miR-449a in lung cancer cells. miR-449a also suppressed tumor formation in vivo in nude mice. These results suggest that miR-449a plays an important role in lung cancer tumorigenesis and that miR-449a might predict cancer recurrence and survival of lung cancer patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Factor de Transcripción E2F3 / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Lett Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Factor de Transcripción E2F3 / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Lett Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda